Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia
Spontaneous pacemaker γ-aminobutyric acid (GABA) receptor-mediated synaptic activity (PGA) occurs in a subset of tissue samples from pediatric epilepsy surgery patients. In the present study, based on single-cell electrophysiological recordings from 120 cases, we describe the etiologies, cell types,...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2014-02-01
|
Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S096999611300274X |
id |
doaj-d211428823114805b7d81fc9d979f307 |
---|---|
record_format |
Article |
spelling |
doaj-d211428823114805b7d81fc9d979f3072021-03-22T12:40:28ZengElsevierNeurobiology of Disease1095-953X2014-02-0162208217Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasiaCarlos Cepeda0Jane Y. Chen1Joyce Y. Wu2Robin S. Fisher3Harry V. Vinters4Gary W. Mathern5Michael S. Levine6Intellectual and Developmental Disabilities Research Center, Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, USA; Corresponding author at: Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience, Room 58-258, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA. Fax: +1 310 206 5060.Intellectual and Developmental Disabilities Research Center, Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, USADivision of Pediatric Neurology, Mattel Children's Hospital, David Geffen School of Medicine, University of California Los Angeles, USAIntellectual and Developmental Disabilities Research Center, Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, USADepartment of Neurology, Section of Neuropathology, David Geffen School of Medicine, University of California Los Angeles, USAIntellectual and Developmental Disabilities Research Center, Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, USA; Department of Neurosurgery, Mattel Children's Hospital, David Geffen School of Medicine, University of California Los Angeles, USA; Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, USAIntellectual and Developmental Disabilities Research Center, Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, USA; Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, USASpontaneous pacemaker γ-aminobutyric acid (GABA) receptor-mediated synaptic activity (PGA) occurs in a subset of tissue samples from pediatric epilepsy surgery patients. In the present study, based on single-cell electrophysiological recordings from 120 cases, we describe the etiologies, cell types, and primary electrophysiological features of PGA. Cells displaying PGA occurred more frequently in the areas of greatest anatomical abnormality in cases of focal cortical dysplasia (CD), often associated with hemimegalencephaly (HME), and only rarely in non-CD etiologies. PGA was characterized by rhythmic synaptic events (5–10 Hz) and was observed in normal-like, dysmorphic cytomegalic, and immature pyramidal neurons. PGA was action potential-dependent, mediated by GABAA receptors, and unaffected by antagonism of glutamate receptors. We propose that PGA is a unique electrophysiological characteristic associated with CD and HME. It could represent an abnormal signal that may contribute to epileptogenesis in malformed postnatal cortex by facilitating pyramidal neuron synchrony.http://www.sciencedirect.com/science/article/pii/S096999611300274XPediatric epilepsyCortical dysplasiaSynaptic activityGABASynchronyDevelopment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carlos Cepeda Jane Y. Chen Joyce Y. Wu Robin S. Fisher Harry V. Vinters Gary W. Mathern Michael S. Levine |
spellingShingle |
Carlos Cepeda Jane Y. Chen Joyce Y. Wu Robin S. Fisher Harry V. Vinters Gary W. Mathern Michael S. Levine Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia Neurobiology of Disease Pediatric epilepsy Cortical dysplasia Synaptic activity GABA Synchrony Development |
author_facet |
Carlos Cepeda Jane Y. Chen Joyce Y. Wu Robin S. Fisher Harry V. Vinters Gary W. Mathern Michael S. Levine |
author_sort |
Carlos Cepeda |
title |
Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia |
title_short |
Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia |
title_full |
Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia |
title_fullStr |
Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia |
title_full_unstemmed |
Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia |
title_sort |
pacemaker gaba synaptic activity may contribute to network synchronization in pediatric cortical dysplasia |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2014-02-01 |
description |
Spontaneous pacemaker γ-aminobutyric acid (GABA) receptor-mediated synaptic activity (PGA) occurs in a subset of tissue samples from pediatric epilepsy surgery patients. In the present study, based on single-cell electrophysiological recordings from 120 cases, we describe the etiologies, cell types, and primary electrophysiological features of PGA. Cells displaying PGA occurred more frequently in the areas of greatest anatomical abnormality in cases of focal cortical dysplasia (CD), often associated with hemimegalencephaly (HME), and only rarely in non-CD etiologies. PGA was characterized by rhythmic synaptic events (5–10 Hz) and was observed in normal-like, dysmorphic cytomegalic, and immature pyramidal neurons. PGA was action potential-dependent, mediated by GABAA receptors, and unaffected by antagonism of glutamate receptors. We propose that PGA is a unique electrophysiological characteristic associated with CD and HME. It could represent an abnormal signal that may contribute to epileptogenesis in malformed postnatal cortex by facilitating pyramidal neuron synchrony. |
topic |
Pediatric epilepsy Cortical dysplasia Synaptic activity GABA Synchrony Development |
url |
http://www.sciencedirect.com/science/article/pii/S096999611300274X |
work_keys_str_mv |
AT carloscepeda pacemakergabasynapticactivitymaycontributetonetworksynchronizationinpediatriccorticaldysplasia AT janeychen pacemakergabasynapticactivitymaycontributetonetworksynchronizationinpediatriccorticaldysplasia AT joyceywu pacemakergabasynapticactivitymaycontributetonetworksynchronizationinpediatriccorticaldysplasia AT robinsfisher pacemakergabasynapticactivitymaycontributetonetworksynchronizationinpediatriccorticaldysplasia AT harryvvinters pacemakergabasynapticactivitymaycontributetonetworksynchronizationinpediatriccorticaldysplasia AT garywmathern pacemakergabasynapticactivitymaycontributetonetworksynchronizationinpediatriccorticaldysplasia AT michaelslevine pacemakergabasynapticactivitymaycontributetonetworksynchronizationinpediatriccorticaldysplasia |
_version_ |
1724208400212951040 |