Sleep Disturbances in Phenylketonuria: An Explorative Study in Men and Mice

Sleep Disturbances in Phenylketonuria: An Explorative Study in Men and Mice

Sleep problems have not been directly reported in phenylketonuria (PKU). In PKU, the metabolic pathway of phenylalanine is disrupted, which, among others, causes deficits in the neurotransmitters and sleep modulators dopamine, norepinephrine, and serotonin. Understanding sleep problems in PKU patien...

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Bibliographic Details
Main Authors: Eddy A. Van der Zee, Vibeke M. Bruinenberg, Marijke C. M. Gordijn, Anita MacDonald, Francjan J. van Spronsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Neurology
Subjects:
inherited metabolic disorder
Pahenu2 mice
phenylketonuria patients
phenylketonuria mice
neurotransmitters
sleep disorders
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2017.00167/full

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