Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genes

• Main Authors: Jing-chao Ren, Huan Liu, Guang-hui Zhang, Tongshuai Wang, Jingzhi Li, Tingting Dong, Hantian Wu, Zhao-lin Xia
• Format: Article
• Language: English
• Published: Elsevier 2020-08-01
• Series: Data in Brief
• Subjects: Benzene; Telomere length; Genetic damage; Micronucleus frequency; Hematotoxicity; Metabolic genes
• Online Access: http://www.sciencedirect.com/science/article/pii/S2352340920307630
• ISSN: 2352-3409

In this paper, we present an occupational dataset to evaluate benzene exposure on the effective biomarkers of genetic damage, indicated as cytokinesis-block micronucleus (MN) frequency, hematotoxicity, indicated as white blood cells (WBC) counts, and molecular marker of telomere length (TL). And we further to eliminate the mechanism of benzene induced damage. Then evaluate the effects of sites polymorphism in environmental response genes, including 18 sites in metabolic and DNA repair genes, and the interaction between gene polymorphism and benzene exposure. This dataset is supplementary to the submitted research by [1] focused on the biomarkers TL, and a detailed description of the subjects sampling, biomarkers detection, data analysis and discussion are discussed in detail.