Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genes

Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genes

In this paper, we present an occupational dataset to evaluate benzene exposure on the effective biomarkers of genetic damage, indicated as cytokinesis-block micronucleus (MN) frequency, hematotoxicity, indicated as white blood cells (WBC) counts, and molecular marker of telomere length (TL). And we...

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Bibliographic Details
Main Authors: Jing-chao Ren, Huan Liu, Guang-hui Zhang, Tongshuai Wang, Jingzhi Li, Tingting Dong, Hantian Wu, Zhao-lin Xia
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Data in Brief
Subjects:
Benzene
Telomere length
Genetic damage
Micronucleus frequency
Hematotoxicity
Metabolic genes
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340920307630
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spelling doaj-d237709045494357a165097601ea92202020-11-25T03:27:55ZengElsevierData in Brief2352-34092020-08-0131105869Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genesJing-chao Ren0Huan Liu1Guang-hui Zhang2Tongshuai Wang3Jingzhi Li4Tingting Dong5Hantian Wu6Zhao-lin Xia7School of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, ChinaSchool of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, ChinaSchool of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, China; Corresponding authors.Department of Occupational Health and Toxicology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, ChinaSchool of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, ChinaSchool of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, ChinaDepartment of Occupational Health and Toxicology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, ChinaDepartment of Occupational Health and Toxicology, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, China; Corresponding authors.In this paper, we present an occupational dataset to evaluate benzene exposure on the effective biomarkers of genetic damage, indicated as cytokinesis-block micronucleus (MN) frequency, hematotoxicity, indicated as white blood cells (WBC) counts, and molecular marker of telomere length (TL). And we further to eliminate the mechanism of benzene induced damage. Then evaluate the effects of sites polymorphism in environmental response genes, including 18 sites in metabolic and DNA repair genes, and the interaction between gene polymorphism and benzene exposure. This dataset is supplementary to the submitted research by [1] focused on the biomarkers TL, and a detailed description of the subjects sampling, biomarkers detection, data analysis and discussion are discussed in detail.http://www.sciencedirect.com/science/article/pii/S2352340920307630BenzeneTelomere lengthGenetic damageMicronucleus frequencyHematotoxicityMetabolic genes
collection DOAJ
language English
format Article
sources DOAJ
author Jing-chao Ren
Huan Liu
Guang-hui Zhang
Tongshuai Wang
Jingzhi Li
Tingting Dong
Hantian Wu
Zhao-lin Xia
spellingShingle Jing-chao Ren
Huan Liu
Guang-hui Zhang
Tongshuai Wang
Jingzhi Li
Tingting Dong
Hantian Wu
Zhao-lin Xia
Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genes
Data in Brief
Benzene
Telomere length
Genetic damage
Micronucleus frequency
Hematotoxicity
Metabolic genes
author_facet Jing-chao Ren
Huan Liu
Guang-hui Zhang
Tongshuai Wang
Jingzhi Li
Tingting Dong
Hantian Wu
Zhao-lin Xia
author_sort Jing-chao Ren
title Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genes
title_short Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genes
title_full Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genes
title_fullStr Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genes
title_full_unstemmed Dataset on the effect of Benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and DNA repair genes
title_sort dataset on the effect of benzene exposure on genetic damage, hematotoxicity, telomere length and polymorphisms in metabolic and dna repair genes
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2020-08-01
description In this paper, we present an occupational dataset to evaluate benzene exposure on the effective biomarkers of genetic damage, indicated as cytokinesis-block micronucleus (MN) frequency, hematotoxicity, indicated as white blood cells (WBC) counts, and molecular marker of telomere length (TL). And we further to eliminate the mechanism of benzene induced damage. Then evaluate the effects of sites polymorphism in environmental response genes, including 18 sites in metabolic and DNA repair genes, and the interaction between gene polymorphism and benzene exposure. This dataset is supplementary to the submitted research by [1] focused on the biomarkers TL, and a detailed description of the subjects sampling, biomarkers detection, data analysis and discussion are discussed in detail.
topic Benzene
Telomere length
Genetic damage
Micronucleus frequency
Hematotoxicity
Metabolic genes
url http://www.sciencedirect.com/science/article/pii/S2352340920307630
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