Rho Family of Ras-Like GTPases in Early-Branching Animals

Rho Family of Ras-Like GTPases in Early-Branching Animals

Non-bilaterian animals consist of four phyla; Porifera, Cnidaria, Ctenophora, and Placozoa. These early-diverging animals are crucial for understanding the evolution of the entire animal lineage. The Rho family of proteins make up a major branch of the Ras superfamily of small GTPases, which functio...

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Main Authors: Silvestar Beljan, Maja Herak Bosnar, Helena Ćetković
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
non-bilaterian animals
Rho GTPases
Cdc24
Rho
Rac
RhoBTB
Online Access:https://www.mdpi.com/2073-4409/9/10/2279
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spelling doaj-d2383f8e0057472aa5f372c7265e23bf2020-11-25T03:53:43ZengMDPI AGCells2073-44092020-10-0192279227910.3390/cells9102279Rho Family of Ras-Like GTPases in Early-Branching AnimalsSilvestar Beljan0Maja Herak Bosnar1Helena Ćetković2Division of Molecular Biology, Ruđer Bošković Institute, HR-10000 Zagreb, CroatiaDivision of Molecular Medicine, Ruđer Bošković Institute, HR-10000 Zagreb, CroatiaDivision of Molecular Biology, Ruđer Bošković Institute, HR-10000 Zagreb, CroatiaNon-bilaterian animals consist of four phyla; Porifera, Cnidaria, Ctenophora, and Placozoa. These early-diverging animals are crucial for understanding the evolution of the entire animal lineage. The Rho family of proteins make up a major branch of the Ras superfamily of small GTPases, which function as key molecular switches that play important roles in converting and amplifying external signals into cellular responses. This review represents a compilation of the current knowledge on Rho-family GTPases in non-bilaterian animals, the available experimental data about their biochemical characteristics and functions, as well as original bioinformatics analysis, in order to gain a general insight into the evolutionary history of Rho-family GTPases in simple animals.https://www.mdpi.com/2073-4409/9/10/2279non-bilaterian animalsRho GTPasesCdc24RhoRacRhoBTB
collection DOAJ
language English
format Article
sources DOAJ
author Silvestar Beljan
Maja Herak Bosnar
Helena Ćetković
spellingShingle Silvestar Beljan
Maja Herak Bosnar
Helena Ćetković
Rho Family of Ras-Like GTPases in Early-Branching Animals
Cells
non-bilaterian animals
Rho GTPases
Cdc24
Rho
Rac
RhoBTB
author_facet Silvestar Beljan
Maja Herak Bosnar
Helena Ćetković
author_sort Silvestar Beljan
title Rho Family of Ras-Like GTPases in Early-Branching Animals
title_short Rho Family of Ras-Like GTPases in Early-Branching Animals
title_full Rho Family of Ras-Like GTPases in Early-Branching Animals
title_fullStr Rho Family of Ras-Like GTPases in Early-Branching Animals
title_full_unstemmed Rho Family of Ras-Like GTPases in Early-Branching Animals
title_sort rho family of ras-like gtpases in early-branching animals
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2020-10-01
description Non-bilaterian animals consist of four phyla; Porifera, Cnidaria, Ctenophora, and Placozoa. These early-diverging animals are crucial for understanding the evolution of the entire animal lineage. The Rho family of proteins make up a major branch of the Ras superfamily of small GTPases, which function as key molecular switches that play important roles in converting and amplifying external signals into cellular responses. This review represents a compilation of the current knowledge on Rho-family GTPases in non-bilaterian animals, the available experimental data about their biochemical characteristics and functions, as well as original bioinformatics analysis, in order to gain a general insight into the evolutionary history of Rho-family GTPases in simple animals.
topic non-bilaterian animals
Rho GTPases
Cdc24
Rho
Rac
RhoBTB
url https://www.mdpi.com/2073-4409/9/10/2279
work_keys_str_mv AT silvestarbeljan rhofamilyofraslikegtpasesinearlybranchinganimals
AT majaherakbosnar rhofamilyofraslikegtpasesinearlybranchinganimals
AT helenacetkovic rhofamilyofraslikegtpasesinearlybranchinganimals
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