A green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using ZrOCl2.8H2O

A convenient, highly efficient and time economic method has been described for the chemo- and regioselective synthesis of 5-aryloyl-1,3,7,9-tetraalkyl-2,8-dithioxo-2,3,8,9-tetrahydro-1H-pyrano[2,3-d:6,5-dˊ]dipyrimidine-4,6(5H,7H)-diones derivatives by one-pot two-component reaction of 1,3-diethyl-2-...

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Main Authors:	Mehdi Rimaz, Hossein Mousavi, Mojgan Behnam, Behzad Khalili
Format:	Article
Language:	English
Published:	Growing Science 2016-09-01
Series:	Current Chemistry Letters
Subjects:	Lewis-acid catalysis Green chemistry Pyranopyrimidine Arylglyoxal One-pot synthesis
Online Access:	http://www.growingscience.com/ccl/Vol5/ccl_2016_12.pdf

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spelling	doaj-d238c9778f5348ce8fb8ecb163fc93382020-11-24T22:59:32ZengGrowing ScienceCurrent Chemistry Letters1927-72961927-730X2016-09-015414515410.5267/j.ccl.2016.8.001A green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using ZrOCl2.8H2O Mehdi RimazHossein MousaviMojgan BehnamBehzad KhaliliA convenient, highly efficient and time economic method has been described for the chemo- and regioselective synthesis of 5-aryloyl-1,3,7,9-tetraalkyl-2,8-dithioxo-2,3,8,9-tetrahydro-1H-pyrano[2,3-d:6,5-dˊ]dipyrimidine-4,6(5H,7H)-diones derivatives by one-pot two-component reaction of 1,3-diethyl-2-thiobarbituric acid or 1,3-dimethyl-2-thiobarbituric acid with substituted arylglyoxalmonohydrates using commercially available zirconium (IV) oxydichloride octahydrate (ZrOCl2.8H2O) as green Lewis acid catalyst. This method is associated with some attractive characteristics such as good selectivity, very short reaction time, high yield of products, cleaner reaction profile, no harmful by-product, cheap and environmental benign catalyst, simple experimental and work-up procedure. This procedure does not require solvent separation and purification steps such as column chromatography.http://www.growingscience.com/ccl/Vol5/ccl_2016_12.pdfLewis-acid catalysis Green chemistryPyranopyrimidineArylglyoxalOne-pot synthesis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mehdi Rimaz Hossein Mousavi Mojgan Behnam Behzad Khalili
spellingShingle	Mehdi Rimaz Hossein Mousavi Mojgan Behnam Behzad Khalili A green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using ZrOCl2.8H2O Current Chemistry Letters Lewis-acid catalysis Green chemistry Pyranopyrimidine Arylglyoxal One-pot synthesis
author_facet	Mehdi Rimaz Hossein Mousavi Mojgan Behnam Behzad Khalili
author_sort	Mehdi Rimaz
title	A green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using ZrOCl2.8H2O
title_short	A green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using ZrOCl2.8H2O
title_full	A green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using ZrOCl2.8H2O
title_fullStr	A green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using ZrOCl2.8H2O
title_full_unstemmed	A green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using ZrOCl2.8H2O
title_sort	green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using zrocl2.8h2o
publisher	Growing Science
series	Current Chemistry Letters
issn	1927-7296 1927-730X
publishDate	2016-09-01
description	A convenient, highly efficient and time economic method has been described for the chemo- and regioselective synthesis of 5-aryloyl-1,3,7,9-tetraalkyl-2,8-dithioxo-2,3,8,9-tetrahydro-1H-pyrano[2,3-d:6,5-dˊ]dipyrimidine-4,6(5H,7H)-diones derivatives by one-pot two-component reaction of 1,3-diethyl-2-thiobarbituric acid or 1,3-dimethyl-2-thiobarbituric acid with substituted arylglyoxalmonohydrates using commercially available zirconium (IV) oxydichloride octahydrate (ZrOCl2.8H2O) as green Lewis acid catalyst. This method is associated with some attractive characteristics such as good selectivity, very short reaction time, high yield of products, cleaner reaction profile, no harmful by-product, cheap and environmental benign catalyst, simple experimental and work-up procedure. This procedure does not require solvent separation and purification steps such as column chromatography.
topic	Lewis-acid catalysis Green chemistry Pyranopyrimidine Arylglyoxal One-pot synthesis
url	http://www.growingscience.com/ccl/Vol5/ccl_2016_12.pdf
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A green chemoselective one-pot protocol for expeditious synthesis of symmetric pyranodipyrimidine derivatives using ZrOCl2.8H2O

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