CD-4/CD-8 lymphocytopenia in HIV negative patients with severe, chronic granulomatous infections
Background: CD-4 lymphocytopenia can occur in acquired immunodeficiency syndrome(AIDS), in severe combined immunodeficiency, with the use of corticosteroids and/or immunosuppressive drugs, and in patients with idiopathic CD-4 lymphocytopenia. The mechanism for the lymphocytopenia is different in eac...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Southwest Respiratory and Critical Care Chronicles
2016-06-01
|
Series: | Southwest Respiratory and Critical Care Chronicles |
Subjects: | |
Online Access: | http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/274 |
id |
doaj-d23ec36bc941400dba7468b030b4f1c3 |
---|---|
record_format |
Article |
spelling |
doaj-d23ec36bc941400dba7468b030b4f1c32020-11-25T02:45:14ZengSouthwest Respiratory and Critical Care ChroniclesSouthwest Respiratory and Critical Care Chronicles2325-92052016-06-014151620254CD-4/CD-8 lymphocytopenia in HIV negative patients with severe, chronic granulomatous infectionsR C Kimbrough0Richard E Winn1S Issarachai2S Suwanvecho3Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock TXDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock TXDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock TXDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock TXBackground: CD-4 lymphocytopenia can occur in acquired immunodeficiency syndrome(AIDS), in severe combined immunodeficiency, with the use of corticosteroids and/or immunosuppressive drugs, and in patients with idiopathic CD-4 lymphocytopenia. The mechanism for the lymphocytopenia is different in each of these illnesses. Objective: Description of HIV-negative patients with severe disseminated tuberculosis or coccidioidomycosis and lymphocytopenia. Settings and patients: All patients were referred to a University Medical Center in Northwest Texas, USA. Four had disseminated tuberculosis, and three had disseminated coccidioidomycosis. Main outcome measures: Follow-up of lymphocyte subset counts and clinical improvement with the treatment of the underlying granulomatous infection. Results: Five patients had an increase in both CD-4 and CD-8 lymphocyte subset counts with treatment of the underlying granulomatous infection. All patients had clinical improvement with initial therapy of the granulomatous infection. One patient succumbed to disseminated tuberculosis (meningitis) and two to disseminated coccidioidomycosis. One patient was lost to follow up. Conclusions: We report a group of HIV-negative patients who had CD-4 lymphocytopenia in response to severe, disseminated, chronic granulomatous infections. With the treatment of the granulomatous infection the lymphocytopenia improved. This finding, coupled with preserved CD-4/CD-8 ratios, can help to differentiate these patients from those with other causes of lymphocytopenia or AIDS.http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/274granulomatous infectiontuberculosislymphocytopeniaCD4-lymphocytescoccidioidomycosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
R C Kimbrough Richard E Winn S Issarachai S Suwanvecho |
spellingShingle |
R C Kimbrough Richard E Winn S Issarachai S Suwanvecho CD-4/CD-8 lymphocytopenia in HIV negative patients with severe, chronic granulomatous infections Southwest Respiratory and Critical Care Chronicles granulomatous infection tuberculosis lymphocytopenia CD4-lymphocytes coccidioidomycosis |
author_facet |
R C Kimbrough Richard E Winn S Issarachai S Suwanvecho |
author_sort |
R C Kimbrough |
title |
CD-4/CD-8 lymphocytopenia in HIV negative patients with severe, chronic granulomatous infections |
title_short |
CD-4/CD-8 lymphocytopenia in HIV negative patients with severe, chronic granulomatous infections |
title_full |
CD-4/CD-8 lymphocytopenia in HIV negative patients with severe, chronic granulomatous infections |
title_fullStr |
CD-4/CD-8 lymphocytopenia in HIV negative patients with severe, chronic granulomatous infections |
title_full_unstemmed |
CD-4/CD-8 lymphocytopenia in HIV negative patients with severe, chronic granulomatous infections |
title_sort |
cd-4/cd-8 lymphocytopenia in hiv negative patients with severe, chronic granulomatous infections |
publisher |
Southwest Respiratory and Critical Care Chronicles |
series |
Southwest Respiratory and Critical Care Chronicles |
issn |
2325-9205 |
publishDate |
2016-06-01 |
description |
Background: CD-4 lymphocytopenia can occur in acquired immunodeficiency syndrome(AIDS), in severe combined immunodeficiency, with the use of corticosteroids and/or immunosuppressive
drugs, and in patients with idiopathic CD-4 lymphocytopenia. The mechanism
for the lymphocytopenia is different in each of these illnesses.
Objective: Description of HIV-negative patients with severe disseminated tuberculosis or
coccidioidomycosis and lymphocytopenia.
Settings and patients: All patients were referred to a University Medical Center in Northwest
Texas, USA. Four had disseminated tuberculosis, and three had disseminated coccidioidomycosis.
Main outcome measures: Follow-up of lymphocyte subset counts and clinical improvement
with the treatment of the underlying granulomatous infection.
Results: Five patients had an increase in both CD-4 and CD-8 lymphocyte subset counts
with treatment of the underlying granulomatous infection. All patients had clinical improvement
with initial therapy of the granulomatous infection. One patient succumbed to disseminated
tuberculosis (meningitis) and two to disseminated coccidioidomycosis. One patient
was lost to follow up.
Conclusions: We report a group of HIV-negative patients who had CD-4 lymphocytopenia
in response to severe, disseminated, chronic granulomatous infections. With the treatment
of the granulomatous infection the lymphocytopenia improved. This finding, coupled
with preserved CD-4/CD-8 ratios, can help to differentiate these patients from those with
other causes of lymphocytopenia or AIDS. |
topic |
granulomatous infection tuberculosis lymphocytopenia CD4-lymphocytes coccidioidomycosis |
url |
http://pulmonarychronicles.com/index.php/pulmonarychronicles/article/view/274 |
work_keys_str_mv |
AT rckimbrough cd4cd8lymphocytopeniainhivnegativepatientswithseverechronicgranulomatousinfections AT richardewinn cd4cd8lymphocytopeniainhivnegativepatientswithseverechronicgranulomatousinfections AT sissarachai cd4cd8lymphocytopeniainhivnegativepatientswithseverechronicgranulomatousinfections AT ssuwanvecho cd4cd8lymphocytopeniainhivnegativepatientswithseverechronicgranulomatousinfections |
_version_ |
1724763371115380736 |