MHC structure and function − antigen presentation. Part 2

• Main Authors: Anna Carla Goldberg, Luiz Vicente Rizzo
• Format: Article
• Language: English
• Published: Instituto Israelita de Ensino e Pesquisa Albert Einstein
• Series: Einstein (São Paulo)
• Subjects: Complexo principal de histocompatibilidade; Apresentação do antígeno; Genes HLA; Resposta imune
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000100028&lng=en&tlng=en

The second part of this review deals with the molecules and processes involved in the processing and presentation of the antigenic fragments to the T-cell receptor. Though the nature of the antigens presented varies, the most significant class of antigens is proteins, processed within the cell to be then recognized in the form of peptides, a mechanism that confers an extraordinary degree of precision to this mode of immune response. The efficiency and accuracy of this system is also the result of the myriad of mechanisms involved in the processing of proteins and production of peptides, in addition to the capture and recycling of alternative sources aiming to generate further diversity in the presentation to T-cells.