MR-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine.
<h4>Objectives</h4>In cases of "spina bifida," a detailed prenatal imaging assessment of the exact morphology of neural tube defects (NTD) is often limited. Due to the diverse clinical prognosis and prenatal treatment options, imaging parameters that support the prenatal differ...
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doaj-d24b1ac7c4784d1283e5b167a4f1e94a2021-03-04T08:47:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11258510.1371/journal.pone.0112585MR-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine.Ramona WoitekAnton DvorakMichael WeberRainer SeidlDieter BettelheimVeronika SchöpfGabriele AmannPeter C BruggerJulia FurtnerUlrika AsenbaumDaniela PrayerGregor Kasprian<h4>Objectives</h4>In cases of "spina bifida," a detailed prenatal imaging assessment of the exact morphology of neural tube defects (NTD) is often limited. Due to the diverse clinical prognosis and prenatal treatment options, imaging parameters that support the prenatal differentiation between open and closed neural tube defects (ONTDs and CNTDs) are required. This fetal MR study aims to evaluate the clivus-supraocciput angle (CSA) and the maximum transverse diameter of the posterior fossa (TDPF) as morphometric parameters to aid in the reliable diagnosis of either ONTDs or CNTDs.<h4>Methods</h4>The TDPF and the CSA of 238 fetuses (20-37 GW, mean: 28.36 GW) with a normal central nervous system, 44 with ONTDS, and 13 with CNTDs (18-37 GW, mean: 24.3 GW) were retrospectively measured using T2-weighted 1.5 Tesla MR -sequences.<h4>Results</h4>Normal fetuses showed a significant increase in the TDPF (r = .956; p<.001) and CSA (r = .714; p<.001) with gestational age. In ONTDs the CSA was significantly smaller (p<.001) than in normal controls and CNTDs, whereas in CNTDs the CSA was not significantly smaller than in controls (p = .160). In both ONTDs and in CNTDs the TDPF was significantly different from controls (p<.001).<h4>Conclusions</h4>The skull base morphology in fetuses with ONTDs differs significantly from cases with CNTDs and normal controls. This is the first study to show that the CSA changes during gestation and that it is a reliable imaging biomarker to distinguish between ONTDs and CNTDs, independent of the morphology of the spinal defect.https://doi.org/10.1371/journal.pone.0112585 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ramona Woitek Anton Dvorak Michael Weber Rainer Seidl Dieter Bettelheim Veronika Schöpf Gabriele Amann Peter C Brugger Julia Furtner Ulrika Asenbaum Daniela Prayer Gregor Kasprian |
spellingShingle |
Ramona Woitek Anton Dvorak Michael Weber Rainer Seidl Dieter Bettelheim Veronika Schöpf Gabriele Amann Peter C Brugger Julia Furtner Ulrika Asenbaum Daniela Prayer Gregor Kasprian MR-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine. PLoS ONE |
author_facet |
Ramona Woitek Anton Dvorak Michael Weber Rainer Seidl Dieter Bettelheim Veronika Schöpf Gabriele Amann Peter C Brugger Julia Furtner Ulrika Asenbaum Daniela Prayer Gregor Kasprian |
author_sort |
Ramona Woitek |
title |
MR-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine. |
title_short |
MR-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine. |
title_full |
MR-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine. |
title_fullStr |
MR-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine. |
title_full_unstemmed |
MR-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine. |
title_sort |
mr-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
<h4>Objectives</h4>In cases of "spina bifida," a detailed prenatal imaging assessment of the exact morphology of neural tube defects (NTD) is often limited. Due to the diverse clinical prognosis and prenatal treatment options, imaging parameters that support the prenatal differentiation between open and closed neural tube defects (ONTDs and CNTDs) are required. This fetal MR study aims to evaluate the clivus-supraocciput angle (CSA) and the maximum transverse diameter of the posterior fossa (TDPF) as morphometric parameters to aid in the reliable diagnosis of either ONTDs or CNTDs.<h4>Methods</h4>The TDPF and the CSA of 238 fetuses (20-37 GW, mean: 28.36 GW) with a normal central nervous system, 44 with ONTDS, and 13 with CNTDs (18-37 GW, mean: 24.3 GW) were retrospectively measured using T2-weighted 1.5 Tesla MR -sequences.<h4>Results</h4>Normal fetuses showed a significant increase in the TDPF (r = .956; p<.001) and CSA (r = .714; p<.001) with gestational age. In ONTDs the CSA was significantly smaller (p<.001) than in normal controls and CNTDs, whereas in CNTDs the CSA was not significantly smaller than in controls (p = .160). In both ONTDs and in CNTDs the TDPF was significantly different from controls (p<.001).<h4>Conclusions</h4>The skull base morphology in fetuses with ONTDs differs significantly from cases with CNTDs and normal controls. This is the first study to show that the CSA changes during gestation and that it is a reliable imaging biomarker to distinguish between ONTDs and CNTDs, independent of the morphology of the spinal defect. |
url |
https://doi.org/10.1371/journal.pone.0112585 |
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