The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis
The epithelium of the lactiferous ducts in the breast is comprised of luminal epithelial cells and underlying basal myoepithelial cells. The regulation of cell fate and transit of cells between these two cell types remains poorly understood. This relationship becomes of greater importance when study...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-09-01
|
Series: | Cancers |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6694/7/3/0866 |
id |
doaj-d2573f8142fb4e96baf95e1749582b5b |
---|---|
record_format |
Article |
spelling |
doaj-d2573f8142fb4e96baf95e1749582b5b2020-11-25T01:05:51ZengMDPI AGCancers2072-66942015-09-01731863188410.3390/cancers7030866cancers7030866The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and MetastasisArwa Flemban0David Qualtrough1Department of Biological, Biomedical and Analytical Sciences, Faculty of Health and Applied Sciences, University of West of England, Bristol BS16 1QY, UKDepartment of Biological, Biomedical and Analytical Sciences, Faculty of Health and Applied Sciences, University of West of England, Bristol BS16 1QY, UKThe epithelium of the lactiferous ducts in the breast is comprised of luminal epithelial cells and underlying basal myoepithelial cells. The regulation of cell fate and transit of cells between these two cell types remains poorly understood. This relationship becomes of greater importance when studying the subtypes of epithelial breast carcinoma, which are categorized according to their expression of luminal or basal markers. The epithelial mesenchymal transition (EMT) is a pivotal event in tumor invasion. It is important to understand mechanisms that regulate this process, which bears relation to the normal dynamic of epithelial/basal phenotype regulation in the mammary gland. Understanding this process could provide answers for the regulation of EMT in breast cancer, and thereby identify potential targets for therapy. Evidence points towards a role for hedgehog signaling in breast tissue homeostasis and also in mammary neoplasia. This review examines our current understanding of role of the hedgehog-signaling (Hh) pathway in breast epithelial cells both during breast development and homeostasis and to assess the potential misappropriation of Hh signals in breast neoplasia, cancer stem cells and tumor metastasis via EMT.http://www.mdpi.com/2072-6694/7/3/0866breast cancerhedgehog signalingmetastasisluminal breast cancerbasal-like breast cancerepithelial mesenchymal transition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arwa Flemban David Qualtrough |
spellingShingle |
Arwa Flemban David Qualtrough The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis Cancers breast cancer hedgehog signaling metastasis luminal breast cancer basal-like breast cancer epithelial mesenchymal transition |
author_facet |
Arwa Flemban David Qualtrough |
author_sort |
Arwa Flemban |
title |
The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis |
title_short |
The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis |
title_full |
The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis |
title_fullStr |
The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis |
title_full_unstemmed |
The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis |
title_sort |
potential role of hedgehog signaling in the luminal/basal phenotype of breast epithelia and in breast cancer invasion and metastasis |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2015-09-01 |
description |
The epithelium of the lactiferous ducts in the breast is comprised of luminal epithelial cells and underlying basal myoepithelial cells. The regulation of cell fate and transit of cells between these two cell types remains poorly understood. This relationship becomes of greater importance when studying the subtypes of epithelial breast carcinoma, which are categorized according to their expression of luminal or basal markers. The epithelial mesenchymal transition (EMT) is a pivotal event in tumor invasion. It is important to understand mechanisms that regulate this process, which bears relation to the normal dynamic of epithelial/basal phenotype regulation in the mammary gland. Understanding this process could provide answers for the regulation of EMT in breast cancer, and thereby identify potential targets for therapy. Evidence points towards a role for hedgehog signaling in breast tissue homeostasis and also in mammary neoplasia. This review examines our current understanding of role of the hedgehog-signaling (Hh) pathway in breast epithelial cells both during breast development and homeostasis and to assess the potential misappropriation of Hh signals in breast neoplasia, cancer stem cells and tumor metastasis via EMT. |
topic |
breast cancer hedgehog signaling metastasis luminal breast cancer basal-like breast cancer epithelial mesenchymal transition |
url |
http://www.mdpi.com/2072-6694/7/3/0866 |
work_keys_str_mv |
AT arwaflemban thepotentialroleofhedgehogsignalingintheluminalbasalphenotypeofbreastepitheliaandinbreastcancerinvasionandmetastasis AT davidqualtrough thepotentialroleofhedgehogsignalingintheluminalbasalphenotypeofbreastepitheliaandinbreastcancerinvasionandmetastasis AT arwaflemban potentialroleofhedgehogsignalingintheluminalbasalphenotypeofbreastepitheliaandinbreastcancerinvasionandmetastasis AT davidqualtrough potentialroleofhedgehogsignalingintheluminalbasalphenotypeofbreastepitheliaandinbreastcancerinvasionandmetastasis |
_version_ |
1725192874554818560 |