Neuronal Death in Newborn Striatum after Hypoxia-Ischemia Is Necrosis and Evolves with Oxidative Stress

Neuronal Death in Newborn Striatum after Hypoxia-Ischemia Is Necrosis and Evolves with Oxidative Stress

The mechanisms for neurodegeneration after hypoxia-ischemia (HI) in newborns are not understood. We tested the hypothesis that striatal neuron death is necrosis and evolves with oxidative stress and selective organelle damage. Piglets (∼1 week old) were used in a model of hypoxia-asphyxia and surviv...

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Bibliographic Details
Main Authors: Lee J. Martin, Ansgar M. Brambrink, Ann C. Price, Adeel Kaiser, Dawn M. Agnew, Rebecca N. Ichord, Richard J. Traystman
Format: Article
Language:English
Published: Elsevier 2000-06-01
Series:Neurobiology of Disease
Subjects:
apoptosis
cerebral palsy
cytochrome c
DNA damage
mitochondria
RNA oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100902821

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