Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression

Andrea Cerase et al. report that the chromatin remodeler Chd8 is a key regulator of mammalian Xist expression and therefore X chromosome inactivation. They find that Chd8 activates Xist expression in embryonic stem cells, while in differentiating cells it acts to prevent spurious Xist expression thr...

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Main Authors:	Andrea Cerase, Alexander N. Young, Nerea Blanes Ruiz, Andreas Buness, Gabrielle M. Sant, Mirjam Arnold, Monica Di Giacomo, Michela Ascolani, Manish Kumar, Andreas Hierholzer, Giuseppe Trigiante, Sarah J. Marzi, Philip Avner
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-04-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-01945-1

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spelling	doaj-d26e720a693341bcb6cd62cfbe1b421b2021-04-18T11:29:43ZengNature Publishing GroupCommunications Biology2399-36422021-04-014111310.1038/s42003-021-01945-1Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expressionAndrea Cerase0Alexander N. Young1Nerea Blanes Ruiz2Andreas Buness3Gabrielle M. Sant4Mirjam Arnold5Monica Di Giacomo6Michela Ascolani7Manish Kumar8Andreas Hierholzer9Giuseppe Trigiante10Sarah J. Marzi11Philip Avner12EMBL-Rome, Epigenetics and Neurobiology UnitEMBL-Rome, Epigenetics and Neurobiology UnitBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonEMBL-Rome, Epigenetics and Neurobiology UnitEMBL-Rome, Epigenetics and Neurobiology UnitEMBL-Rome, Epigenetics and Neurobiology UnitEMBL-Rome, Epigenetics and Neurobiology UnitEMBL-Rome, Epigenetics and Neurobiology UnitEMBL-Rome, Epigenetics and Neurobiology UnitEMBL-Rome, Epigenetics and Neurobiology UnitBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonUK Dementia Research Institute, Imperial College LondonEMBL-Rome, Epigenetics and Neurobiology UnitAndrea Cerase et al. report that the chromatin remodeler Chd8 is a key regulator of mammalian Xist expression and therefore X chromosome inactivation. They find that Chd8 activates Xist expression in embryonic stem cells, while in differentiating cells it acts to prevent spurious Xist expression through blocking transcription factor binding to the Xist promoter.https://doi.org/10.1038/s42003-021-01945-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Andrea Cerase Alexander N. Young Nerea Blanes Ruiz Andreas Buness Gabrielle M. Sant Mirjam Arnold Monica Di Giacomo Michela Ascolani Manish Kumar Andreas Hierholzer Giuseppe Trigiante Sarah J. Marzi Philip Avner
spellingShingle	Andrea Cerase Alexander N. Young Nerea Blanes Ruiz Andreas Buness Gabrielle M. Sant Mirjam Arnold Monica Di Giacomo Michela Ascolani Manish Kumar Andreas Hierholzer Giuseppe Trigiante Sarah J. Marzi Philip Avner Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression Communications Biology
author_facet	Andrea Cerase Alexander N. Young Nerea Blanes Ruiz Andreas Buness Gabrielle M. Sant Mirjam Arnold Monica Di Giacomo Michela Ascolani Manish Kumar Andreas Hierholzer Giuseppe Trigiante Sarah J. Marzi Philip Avner
author_sort	Andrea Cerase
title	Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
title_short	Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
title_full	Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
title_fullStr	Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
title_full_unstemmed	Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression
title_sort	chd8 regulates x chromosome inactivation in mouse through fine-tuning control of xist expression
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-04-01
description	Andrea Cerase et al. report that the chromatin remodeler Chd8 is a key regulator of mammalian Xist expression and therefore X chromosome inactivation. They find that Chd8 activates Xist expression in embryonic stem cells, while in differentiating cells it acts to prevent spurious Xist expression through blocking transcription factor binding to the Xist promoter.
url	https://doi.org/10.1038/s42003-021-01945-1
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Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression

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