MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern Spain
A limited number of studies have been performed so far on the polymorphism in the transmembrane region (exon 5) of the major histocompatibility complex class I chain-related gene A (MICA) in patients with melanoma. However, the influence of MICA polymorphism in extracellular domains (exons 2, 3, and...
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Format: | Article |
Language: | English |
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Hindawi Limited
2015-01-01
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Series: | Disease Markers |
Online Access: | http://dx.doi.org/10.1155/2015/831864 |
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doaj-d270d1dceca34f44a9ad47f482091c2f |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
José Antonio Campillo Ruth López-Hernández Helios Martínez-Banaclocha José Miguel Bolarín Lourdes Gimeno Anna Mrowiec Manuela López Beatriz Las Heras Alfredo Minguela Maria Rosa Moya-Quiles Isabel Legáz José Francisco Frías-Iniesta Ana María García-Alonso María Rocío Álvarez-López Jorge Antonio Martínez-Escribano Manuel Muro |
spellingShingle |
José Antonio Campillo Ruth López-Hernández Helios Martínez-Banaclocha José Miguel Bolarín Lourdes Gimeno Anna Mrowiec Manuela López Beatriz Las Heras Alfredo Minguela Maria Rosa Moya-Quiles Isabel Legáz José Francisco Frías-Iniesta Ana María García-Alonso María Rocío Álvarez-López Jorge Antonio Martínez-Escribano Manuel Muro MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern Spain Disease Markers |
author_facet |
José Antonio Campillo Ruth López-Hernández Helios Martínez-Banaclocha José Miguel Bolarín Lourdes Gimeno Anna Mrowiec Manuela López Beatriz Las Heras Alfredo Minguela Maria Rosa Moya-Quiles Isabel Legáz José Francisco Frías-Iniesta Ana María García-Alonso María Rocío Álvarez-López Jorge Antonio Martínez-Escribano Manuel Muro |
author_sort |
José Antonio Campillo |
title |
MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern Spain |
title_short |
MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern Spain |
title_full |
MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern Spain |
title_fullStr |
MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern Spain |
title_full_unstemmed |
MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern Spain |
title_sort |
mhc class i chain-related gene a diversity in patients with cutaneous malignant melanoma from southeastern spain |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2015-01-01 |
description |
A limited number of studies have been performed so far on the polymorphism in the transmembrane region (exon 5) of the major histocompatibility complex class I chain-related gene A (MICA) in patients with melanoma. However, the influence of MICA polymorphism in extracellular domains (exons 2, 3, and 4) has not been investigated on melanoma disease. This study aims to characterize the influence of extracellular MICA polymorphism, and its previously described linkage disequilibrium with HLA-B locus, on patients with cutaneous melanoma from southeastern Spain. For this purpose, MICA and HLA-B genotyping was performed in 233 patients and 200 ethnically matched controls by luminex technology. Patients were classified according to the presence of methionine or valine at codon 129 of MICA gene. We found a high frequency of MICA*009 in melanoma patients compared with controls (P=0.002, Pc = 0.03). Our results also showed an association between MICA*009 and HLA-B*51 alleles in both patients and controls. This association was stronger in patients than controls (P=0.015). However, a multivariate logistic regression model showed that neither MICA*009 nor the combination MICA*009/HLA-B*51 was associated with melanoma susceptibility. No relationship was observed between MICA-129 dimorphism and melanoma nor when MICA polymorphism was evaluated according to clinical findings at diagnosis. |
url |
http://dx.doi.org/10.1155/2015/831864 |
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doaj-d270d1dceca34f44a9ad47f482091c2f2020-11-24T23:54:02ZengHindawi LimitedDisease Markers0278-02401875-86302015-01-01201510.1155/2015/831864831864MHC Class I Chain-Related Gene A Diversity in Patients with Cutaneous Malignant Melanoma from Southeastern SpainJosé Antonio Campillo0Ruth López-Hernández1Helios Martínez-Banaclocha2José Miguel Bolarín3Lourdes Gimeno4Anna Mrowiec5Manuela López6Beatriz Las Heras7Alfredo Minguela8Maria Rosa Moya-Quiles9Isabel Legáz10José Francisco Frías-Iniesta11Ana María García-Alonso12María Rocío Álvarez-López13Jorge Antonio Martínez-Escribano14Manuel Muro15Immunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainDermatology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainDermatology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainImmunology Department, University Clinical Hospital Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar, 30120 Murcia, SpainA limited number of studies have been performed so far on the polymorphism in the transmembrane region (exon 5) of the major histocompatibility complex class I chain-related gene A (MICA) in patients with melanoma. However, the influence of MICA polymorphism in extracellular domains (exons 2, 3, and 4) has not been investigated on melanoma disease. This study aims to characterize the influence of extracellular MICA polymorphism, and its previously described linkage disequilibrium with HLA-B locus, on patients with cutaneous melanoma from southeastern Spain. For this purpose, MICA and HLA-B genotyping was performed in 233 patients and 200 ethnically matched controls by luminex technology. Patients were classified according to the presence of methionine or valine at codon 129 of MICA gene. We found a high frequency of MICA*009 in melanoma patients compared with controls (P=0.002, Pc = 0.03). Our results also showed an association between MICA*009 and HLA-B*51 alleles in both patients and controls. This association was stronger in patients than controls (P=0.015). However, a multivariate logistic regression model showed that neither MICA*009 nor the combination MICA*009/HLA-B*51 was associated with melanoma susceptibility. No relationship was observed between MICA-129 dimorphism and melanoma nor when MICA polymorphism was evaluated according to clinical findings at diagnosis.http://dx.doi.org/10.1155/2015/831864 |