Adjuvant Therapy: Melanoma
With an incidence that is increasing at 2–5% per year, cutaneous melanoma is an international scourge that disproportionately targets young individuals. Despite much research, the treatment of advanced disease is still quite challenging. Immunotherapy with high-dose interferon-α2b or interleukin-2 b...
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Online Access: | http://dx.doi.org/10.1155/2011/274382 |
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doaj-d2751995ce7c41e291548e1597271d192020-11-24T22:58:17ZengHindawi LimitedJournal of Skin Cancer2090-29052090-29132011-01-01201110.1155/2011/274382274382Adjuvant Therapy: MelanomaDiwakar Davar0Ahmad Tarhini1John M. Kirkwood2Division of General Internal Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USADivision of Hematology-Oncology, University of Pittsburgh Medical Center, 5150 Centre Avenue, Pittsburgh, PA 15232, USADivision of Hematology-Oncology, University of Pittsburgh Medical Center, 5150 Centre Avenue, Pittsburgh, PA 15232, USAWith an incidence that is increasing at 2–5% per year, cutaneous melanoma is an international scourge that disproportionately targets young individuals. Despite much research, the treatment of advanced disease is still quite challenging. Immunotherapy with high-dose interferon-α2b or interleukin-2 benefits a select group of patients in the adjuvant and metastatic settings, respectively, with significant attendant toxicity. Advances in the biology of malignant melanoma and the role of immunomodulatory therapy have produced advances that have stunned the field. In this paper, we review the data for the use of interferon-α2b in various dosing ranges, vaccine therapy, and the role of radiotherapy in the adjuvant setting for malignant melanoma. Recent trials in the metastatic setting using anticytoxic T-lymphocyte antigen-4 (anti-CTLA-4) monoclonal antibody therapy and BRAF inhibitor therapy have demonstrated clear benefit with prolongation of survival. Trials investigating combinations of these novel agents with existing immunomodulators are at present underway.http://dx.doi.org/10.1155/2011/274382 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diwakar Davar Ahmad Tarhini John M. Kirkwood |
spellingShingle |
Diwakar Davar Ahmad Tarhini John M. Kirkwood Adjuvant Therapy: Melanoma Journal of Skin Cancer |
author_facet |
Diwakar Davar Ahmad Tarhini John M. Kirkwood |
author_sort |
Diwakar Davar |
title |
Adjuvant Therapy: Melanoma |
title_short |
Adjuvant Therapy: Melanoma |
title_full |
Adjuvant Therapy: Melanoma |
title_fullStr |
Adjuvant Therapy: Melanoma |
title_full_unstemmed |
Adjuvant Therapy: Melanoma |
title_sort |
adjuvant therapy: melanoma |
publisher |
Hindawi Limited |
series |
Journal of Skin Cancer |
issn |
2090-2905 2090-2913 |
publishDate |
2011-01-01 |
description |
With an incidence that is increasing at 2–5% per year, cutaneous melanoma is an international scourge that disproportionately targets young individuals. Despite much research, the treatment of advanced disease is still quite challenging. Immunotherapy with high-dose interferon-α2b or interleukin-2 benefits a select group of patients in the adjuvant and metastatic settings, respectively, with significant attendant toxicity. Advances in the biology of malignant melanoma and the role of immunomodulatory therapy have produced advances that have stunned the field. In this paper, we review the data for the use of interferon-α2b in various dosing ranges, vaccine therapy, and the role of radiotherapy in the adjuvant setting for malignant melanoma. Recent trials in the metastatic setting using anticytoxic T-lymphocyte antigen-4 (anti-CTLA-4) monoclonal antibody therapy and BRAF inhibitor therapy have demonstrated clear benefit with prolongation of survival. Trials investigating combinations of these novel agents with existing immunomodulators are at present underway. |
url |
http://dx.doi.org/10.1155/2011/274382 |
work_keys_str_mv |
AT diwakardavar adjuvanttherapymelanoma AT ahmadtarhini adjuvanttherapymelanoma AT johnmkirkwood adjuvanttherapymelanoma |
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1725647770148143104 |