Genes contributing to genetic variation of muscling in sheep
Selective breeding programs aiming to increase the productivity and profitability of the sheep meat industry use elite, progeny tested sires. The broad genetic traits of primary interest in the progeny of these sires include skeletal muscle yield, fat content, eating quality and reproductive efficie...
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Frontiers Media S.A.
2012-08-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00164/full |
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doaj-d27cc266a8a949e1ad69bdde5feb49e82020-11-25T01:07:44ZengFrontiers Media S.A.Frontiers in Genetics1664-80212012-08-01310.3389/fgene.2012.0016432370Genes contributing to genetic variation of muscling in sheepRoss L Tellam0Noelle E. Cockett1Tony eVuocolo2Christopher A Bidwell3CSIROUtah State UniversityCSIROPurdue UniversitySelective breeding programs aiming to increase the productivity and profitability of the sheep meat industry use elite, progeny tested sires. The broad genetic traits of primary interest in the progeny of these sires include skeletal muscle yield, fat content, eating quality and reproductive efficiency. Natural mutations in sheep that enhance muscling have been identified, while a number of genome scans have identified and confirmed quantitative trait loci for skeletal muscle traits. The detailed phenotypic characteristics of sheep carrying these mutations or quantitative trait loci affecting skeletal muscle show a number of common biological themes, particularly changes in developmental growth trajectories, alterations of whole animal morphology and a shift towards fast twitch glycolytic fibres. The genetic, developmental and biochemical mechanisms underpinning the actions of some of these genetic variants are described. This review critically assesses this research area, identifies gaps in knowledge and highlights mechanistic linkages between genetic polymorphisms and skeletal muscle phenotypic changes. This knowledge may aid the discovery of new causal genetic variants and in some cases lead to the development of biochemical and immunological strategies aimed at enhancing skeletal muscle.http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00164/fullMyostatinSheepgeneskeletal muscleCallipyge |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ross L Tellam Noelle E. Cockett Tony eVuocolo Christopher A Bidwell |
spellingShingle |
Ross L Tellam Noelle E. Cockett Tony eVuocolo Christopher A Bidwell Genes contributing to genetic variation of muscling in sheep Frontiers in Genetics Myostatin Sheep gene skeletal muscle Callipyge |
author_facet |
Ross L Tellam Noelle E. Cockett Tony eVuocolo Christopher A Bidwell |
author_sort |
Ross L Tellam |
title |
Genes contributing to genetic variation of muscling in sheep |
title_short |
Genes contributing to genetic variation of muscling in sheep |
title_full |
Genes contributing to genetic variation of muscling in sheep |
title_fullStr |
Genes contributing to genetic variation of muscling in sheep |
title_full_unstemmed |
Genes contributing to genetic variation of muscling in sheep |
title_sort |
genes contributing to genetic variation of muscling in sheep |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2012-08-01 |
description |
Selective breeding programs aiming to increase the productivity and profitability of the sheep meat industry use elite, progeny tested sires. The broad genetic traits of primary interest in the progeny of these sires include skeletal muscle yield, fat content, eating quality and reproductive efficiency. Natural mutations in sheep that enhance muscling have been identified, while a number of genome scans have identified and confirmed quantitative trait loci for skeletal muscle traits. The detailed phenotypic characteristics of sheep carrying these mutations or quantitative trait loci affecting skeletal muscle show a number of common biological themes, particularly changes in developmental growth trajectories, alterations of whole animal morphology and a shift towards fast twitch glycolytic fibres. The genetic, developmental and biochemical mechanisms underpinning the actions of some of these genetic variants are described. This review critically assesses this research area, identifies gaps in knowledge and highlights mechanistic linkages between genetic polymorphisms and skeletal muscle phenotypic changes. This knowledge may aid the discovery of new causal genetic variants and in some cases lead to the development of biochemical and immunological strategies aimed at enhancing skeletal muscle. |
topic |
Myostatin Sheep gene skeletal muscle Callipyge |
url |
http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00164/full |
work_keys_str_mv |
AT rossltellam genescontributingtogeneticvariationofmusclinginsheep AT noelleecockett genescontributingtogeneticvariationofmusclinginsheep AT tonyevuocolo genescontributingtogeneticvariationofmusclinginsheep AT christopherabidwell genescontributingtogeneticvariationofmusclinginsheep |
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