A randomized double-blind placebo-controlled clinical study on the effects of gabapentin premedication on hemodynamic stability during laparoscopic cholecystectomy

• Main Authors: Mausumi Neogi, Santanu Basak, Debasis Ghosh, Sandip Mukherjee, Satrajit Dawn, Dhurjoti P Bhattacharjee
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2012-01-01
• Series: Journal of Anaesthesiology Clinical Pharmacology
• Subjects: Gabapentin; hemodynamics; laparoscopic surgery
• Online Access: http://www.joacp.org/article.asp?issn=0970-9185;year=2012;volume=28;issue=4;spage=456;epage=459;aulast=Neogi

Background: Carbon dioxide pneumoperitoneum for laparoscopic surgery increases arterial pressures, heart rate, and systemic vascular resistance. In this randomized double-blind placebo-controlled clinical study, we investigated the efficacy of gabapentin premedication to provide perioperative hemodynamic stability in patients undergoing laparoscopic cholecystectomy. Materials and Methods: Sixty patients, of either sex (18-65 years of age) undergoing elective laparoscopic cholecystectomy were randomly allocated to two groups of 30 patients each. Patients of group G received oral gabapentin 900 mg 2 h before induction of anesthesia, while patients in group P received placebo at the same time. Results: Mean arterial pressure in patients of group G were significantly lower (P < 0.05) after tracheal intubation and pneumoperitoneum and remained lower, as compared to group P, throughout the pneumoperitoneum. Similarly, heart rate in group G was significantly lower (P < 0.05) after tracheal intubation and pneumoperitoneum and remained lower, in comparison to group P, throughout the peumoperitoneum. Intravenous labetalol was required, to control intraoperative hypertension, in 33.3% (10 out of 30) patients in group P. There was no significant difference in the incidence of adverse effects between the two groups. Conclusion: Gabapentin premedication provided perioperative hemodynamic stability during laparoscopic surgery.