Single-molecule photoreaction quantitation through intraparticle-surface energy transfer (i-SET) spectroscopy

Single-molecule photoreaction quantitation through intraparticle-surface energy transfer (i-SET) spectroscopy

Single-molecule sensing is very challenging due to weak emitted signals and environmental interference. Here the authors design a method (i-SET) for single molecule sensing with core-shell upconverting nanoparticles, which relies on signal enhancement by the activator-rich probes to quantify fluorop...

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Main Authors: Jian Zhou, Changyu Li, Denghao Li, Xiaofeng Liu, Zhao Mu, Weibo Gao, Jianrong Qiu, Renren Deng
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18223-z
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spelling doaj-d28b5704d1be44959aa8f253bf81b4932021-08-29T11:39:00ZengNature Publishing GroupNature Communications2041-17232020-08-011111810.1038/s41467-020-18223-zSingle-molecule photoreaction quantitation through intraparticle-surface energy transfer (i-SET) spectroscopyJian Zhou0Changyu Li1Denghao Li2Xiaofeng Liu3Zhao Mu4Weibo Gao5Jianrong Qiu6Renren Deng7Institute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang UniversityInstitute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang UniversityInstitute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang UniversityInstitute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang UniversityDivision of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological UniversityDivision of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological UniversityState Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang UniversityInstitute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang UniversitySingle-molecule sensing is very challenging due to weak emitted signals and environmental interference. Here the authors design a method (i-SET) for single molecule sensing with core-shell upconverting nanoparticles, which relies on signal enhancement by the activator-rich probes to quantify fluorophores attached to a single nanoparticle.https://doi.org/10.1038/s41467-020-18223-z
collection DOAJ
language English
format Article
sources DOAJ
author Jian Zhou
Changyu Li
Denghao Li
Xiaofeng Liu
Zhao Mu
Weibo Gao
Jianrong Qiu
Renren Deng
spellingShingle Jian Zhou
Changyu Li
Denghao Li
Xiaofeng Liu
Zhao Mu
Weibo Gao
Jianrong Qiu
Renren Deng
Single-molecule photoreaction quantitation through intraparticle-surface energy transfer (i-SET) spectroscopy
Nature Communications
author_facet Jian Zhou
Changyu Li
Denghao Li
Xiaofeng Liu
Zhao Mu
Weibo Gao
Jianrong Qiu
Renren Deng
author_sort Jian Zhou
title Single-molecule photoreaction quantitation through intraparticle-surface energy transfer (i-SET) spectroscopy
title_short Single-molecule photoreaction quantitation through intraparticle-surface energy transfer (i-SET) spectroscopy
title_full Single-molecule photoreaction quantitation through intraparticle-surface energy transfer (i-SET) spectroscopy
title_fullStr Single-molecule photoreaction quantitation through intraparticle-surface energy transfer (i-SET) spectroscopy
title_full_unstemmed Single-molecule photoreaction quantitation through intraparticle-surface energy transfer (i-SET) spectroscopy
title_sort single-molecule photoreaction quantitation through intraparticle-surface energy transfer (i-set) spectroscopy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-08-01
description Single-molecule sensing is very challenging due to weak emitted signals and environmental interference. Here the authors design a method (i-SET) for single molecule sensing with core-shell upconverting nanoparticles, which relies on signal enhancement by the activator-rich probes to quantify fluorophores attached to a single nanoparticle.
url https://doi.org/10.1038/s41467-020-18223-z
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AT changyuli singlemoleculephotoreactionquantitationthroughintraparticlesurfaceenergytransferisetspectroscopy
AT denghaoli singlemoleculephotoreactionquantitationthroughintraparticlesurfaceenergytransferisetspectroscopy
AT xiaofengliu singlemoleculephotoreactionquantitationthroughintraparticlesurfaceenergytransferisetspectroscopy
AT zhaomu singlemoleculephotoreactionquantitationthroughintraparticlesurfaceenergytransferisetspectroscopy
AT weibogao singlemoleculephotoreactionquantitationthroughintraparticlesurfaceenergytransferisetspectroscopy
AT jianrongqiu singlemoleculephotoreactionquantitationthroughintraparticlesurfaceenergytransferisetspectroscopy
AT renrendeng singlemoleculephotoreactionquantitationthroughintraparticlesurfaceenergytransferisetspectroscopy
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