A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure
Intraocular pressure (IOP) is a major risk factor for glaucoma. Here, Choquet and co-authors perform a multi-ethnic genome-wide association study of repeat IOP measurements in 69,756 individuals and identify 40 novel loci, 36 of which show directionally consistent effects in glaucoma.
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2017-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-01913-6 |
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doaj-d28f9a2d6c08476a9173b4a2e84096892021-05-11T07:15:52ZengNature Publishing GroupNature Communications2041-17232017-12-01811910.1038/s41467-017-01913-6A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressureHélène Choquet0Khanh K. Thai1Jie Yin2Thomas J. Hoffmann3Mark N. Kvale4Yambazi Banda5Catherine Schaefer6Neil Risch7K. Saidas Nair8Ronald Melles9Eric Jorgenson10Kaiser Permanente Northern California (KPNC), Division of ResearchKaiser Permanente Northern California (KPNC), Division of ResearchKaiser Permanente Northern California (KPNC), Division of ResearchInstitute for Human Genetics, University of California San Francisco (UCSF)Institute for Human Genetics, University of California San Francisco (UCSF)Institute for Human Genetics, University of California San Francisco (UCSF)Kaiser Permanente Northern California (KPNC), Division of ResearchKaiser Permanente Northern California (KPNC), Division of ResearchDepartments of Ophthalmology and Anatomy, School of Medicine, UCSFKPNC, Department of OphthalmologyKaiser Permanente Northern California (KPNC), Division of ResearchIntraocular pressure (IOP) is a major risk factor for glaucoma. Here, Choquet and co-authors perform a multi-ethnic genome-wide association study of repeat IOP measurements in 69,756 individuals and identify 40 novel loci, 36 of which show directionally consistent effects in glaucoma.https://doi.org/10.1038/s41467-017-01913-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hélène Choquet Khanh K. Thai Jie Yin Thomas J. Hoffmann Mark N. Kvale Yambazi Banda Catherine Schaefer Neil Risch K. Saidas Nair Ronald Melles Eric Jorgenson |
spellingShingle |
Hélène Choquet Khanh K. Thai Jie Yin Thomas J. Hoffmann Mark N. Kvale Yambazi Banda Catherine Schaefer Neil Risch K. Saidas Nair Ronald Melles Eric Jorgenson A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure Nature Communications |
author_facet |
Hélène Choquet Khanh K. Thai Jie Yin Thomas J. Hoffmann Mark N. Kvale Yambazi Banda Catherine Schaefer Neil Risch K. Saidas Nair Ronald Melles Eric Jorgenson |
author_sort |
Hélène Choquet |
title |
A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure |
title_short |
A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure |
title_full |
A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure |
title_fullStr |
A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure |
title_full_unstemmed |
A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure |
title_sort |
large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-12-01 |
description |
Intraocular pressure (IOP) is a major risk factor for glaucoma. Here, Choquet and co-authors perform a multi-ethnic genome-wide association study of repeat IOP measurements in 69,756 individuals and identify 40 novel loci, 36 of which show directionally consistent effects in glaucoma. |
url |
https://doi.org/10.1038/s41467-017-01913-6 |
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