A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure

Intraocular pressure (IOP) is a major risk factor for glaucoma. Here, Choquet and co-authors perform a multi-ethnic genome-wide association study of repeat IOP measurements in 69,756 individuals and identify 40 novel loci, 36 of which show directionally consistent effects in glaucoma.

Bibliographic Details
Main Authors:	Hélène Choquet, Khanh K. Thai, Jie Yin, Thomas J. Hoffmann, Mark N. Kvale, Yambazi Banda, Catherine Schaefer, Neil Risch, K. Saidas Nair, Ronald Melles, Eric Jorgenson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01913-6

id	doaj-d28f9a2d6c08476a9173b4a2e8409689
record_format	Article
spelling	doaj-d28f9a2d6c08476a9173b4a2e84096892021-05-11T07:15:52ZengNature Publishing GroupNature Communications2041-17232017-12-01811910.1038/s41467-017-01913-6A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressureHélène Choquet0Khanh K. Thai1Jie Yin2Thomas J. Hoffmann3Mark N. Kvale4Yambazi Banda5Catherine Schaefer6Neil Risch7K. Saidas Nair8Ronald Melles9Eric Jorgenson10Kaiser Permanente Northern California (KPNC), Division of ResearchKaiser Permanente Northern California (KPNC), Division of ResearchKaiser Permanente Northern California (KPNC), Division of ResearchInstitute for Human Genetics, University of California San Francisco (UCSF)Institute for Human Genetics, University of California San Francisco (UCSF)Institute for Human Genetics, University of California San Francisco (UCSF)Kaiser Permanente Northern California (KPNC), Division of ResearchKaiser Permanente Northern California (KPNC), Division of ResearchDepartments of Ophthalmology and Anatomy, School of Medicine, UCSFKPNC, Department of OphthalmologyKaiser Permanente Northern California (KPNC), Division of ResearchIntraocular pressure (IOP) is a major risk factor for glaucoma. Here, Choquet and co-authors perform a multi-ethnic genome-wide association study of repeat IOP measurements in 69,756 individuals and identify 40 novel loci, 36 of which show directionally consistent effects in glaucoma.https://doi.org/10.1038/s41467-017-01913-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hélène Choquet Khanh K. Thai Jie Yin Thomas J. Hoffmann Mark N. Kvale Yambazi Banda Catherine Schaefer Neil Risch K. Saidas Nair Ronald Melles Eric Jorgenson
spellingShingle	Hélène Choquet Khanh K. Thai Jie Yin Thomas J. Hoffmann Mark N. Kvale Yambazi Banda Catherine Schaefer Neil Risch K. Saidas Nair Ronald Melles Eric Jorgenson A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure Nature Communications
author_facet	Hélène Choquet Khanh K. Thai Jie Yin Thomas J. Hoffmann Mark N. Kvale Yambazi Banda Catherine Schaefer Neil Risch K. Saidas Nair Ronald Melles Eric Jorgenson
author_sort	Hélène Choquet
title	A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure
title_short	A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure
title_full	A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure
title_fullStr	A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure
title_full_unstemmed	A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure
title_sort	large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	Intraocular pressure (IOP) is a major risk factor for glaucoma. Here, Choquet and co-authors perform a multi-ethnic genome-wide association study of repeat IOP measurements in 69,756 individuals and identify 40 novel loci, 36 of which show directionally consistent effects in glaucoma.
url	https://doi.org/10.1038/s41467-017-01913-6
work_keys_str_mv	AT helenechoquet alargemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT khanhkthai alargemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT jieyin alargemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT thomasjhoffmann alargemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT marknkvale alargemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT yambazibanda alargemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT catherineschaefer alargemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT neilrisch alargemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT ksaidasnair alargemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT ronaldmelles alargemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT ericjorgenson alargemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT helenechoquet largemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT khanhkthai largemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT jieyin largemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT thomasjhoffmann largemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT marknkvale largemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT yambazibanda largemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT catherineschaefer largemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT neilrisch largemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT ksaidasnair largemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT ronaldmelles largemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure AT ericjorgenson largemultiethnicgenomewideassociationstudyidentifiesnovelgeneticlociforintraocularpressure
_version_	1721452513394163712

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure

Similar Items