DsbA-L Ameliorates Renal Injury Through the AMPK/NLRP3 Inflammasome Signaling Pathway in Diabetic Nephropathy

DsbA-L Ameliorates Renal Injury Through the AMPK/NLRP3 Inflammasome Signaling Pathway in Diabetic Nephropathy

NLRP3-mediated inflammation is closely related to the pathological progression of diabetic nephropathy (DN). DsbA-L, an antioxidant enzyme, plays a protective role in a variety of diseases by inhibiting ER stress and regulating metabolism. However, the relationship of DsbA-L with inflammation, espec...

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Bibliographic Details
Main Authors: Ming Yang, Shilu Luo, Na Jiang, Xi Wang, Yachun Han, Hao Zhao, Xiaofen Xiong, Yan Liu, Chanyue Zhao, Xuejing Zhu, Lin Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Physiology
Subjects:
NLRP3 inflammasome
DsbA-L
AMPK
diabetic nephropathy
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.659751/full

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