GIP-induced vasodilation in human adipose tissue involves capillary recruitment
Glucose-dependent insulinotropic polypeptide (GIP) in combination with hyperinsulinemia increase blood flow and triglyceride clearance in subcutaneous abdominal adipose tissue in lean humans. The present experiments were performed to determine whether the increase involves capillary recruitment. Eig...
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Bioscientifica
2019-06-01
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doaj-d2b054bf70a34ab2b4d4d17fca33a86b2020-11-25T01:12:18ZengBioscientificaEndocrine Connections2049-36142049-36142019-06-0186806813https://doi.org/10.1530/EC-19-0144GIP-induced vasodilation in human adipose tissue involves capillary recruitmentMeena Asmar0Ali Asmar1Lene Simonsen2Flemming Dela3Jens Juul Holst4Jens Bülow5Department of Endocrinology, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark; Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, DenmarkXlab, Center for Healthy Ageing, University of Copenhagen, Copenhagen, Denmark; Department of Geriatrics, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, DenmarkNNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, DenmarkGlucose-dependent insulinotropic polypeptide (GIP) in combination with hyperinsulinemia increase blood flow and triglyceride clearance in subcutaneous abdominal adipose tissue in lean humans. The present experiments were performed to determine whether the increase involves capillary recruitment. Eight lean healthy volunteers were studied before and after 1 h infusion of GIP or saline during a hyperglycemic–hyperinsulinemic clamp, raising plasma glucose and insulin to postprandial levels. Subcutaneous abdominal adipose tissue blood flow (ATBF) was measured by the 133Xenon clearance technique, and microvascular blood volume was determined by contrast-enhanced ultrasound imaging.During infusion of saline and the clamp, both ATBF (2.7 ± 0.5 m L/min 100 g/tissue) and microvascular blood volume remained unchanged throughout the experiments. During GIP infusion and the clamp, ATBF increased ~fourfold to 11.4 ± 1.9 mL/min 100 g/tissue, P < 0.001. Likewise, the contrast-enhanced ultrasound signal intensity, a measure of the microvascular blood volume, increased significantly 1 h after in fusion of GIP and the clamp (P = 0.003), but not in the control experiments. In conclusion, the increase in ATBF during GIP infusion involves recruitment of capillaries in healthy lean subjects, which probably increases the interaction of circulating lipoproteins with lipoprotein lipase, thus promoting adipose tissue lipid uptake.https://ec.bioscientifica.com/view/journals/ec/8/6/EC-19-0144.xmlglucose dependent insulinotropic polypeptideadipose tissueblood flowultrasonic imagingmicrocirculation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meena Asmar Ali Asmar Lene Simonsen Flemming Dela Jens Juul Holst Jens Bülow |
spellingShingle |
Meena Asmar Ali Asmar Lene Simonsen Flemming Dela Jens Juul Holst Jens Bülow GIP-induced vasodilation in human adipose tissue involves capillary recruitment Endocrine Connections glucose dependent insulinotropic polypeptide adipose tissue blood flow ultrasonic imaging microcirculation |
author_facet |
Meena Asmar Ali Asmar Lene Simonsen Flemming Dela Jens Juul Holst Jens Bülow |
author_sort |
Meena Asmar |
title |
GIP-induced vasodilation in human adipose tissue involves capillary recruitment |
title_short |
GIP-induced vasodilation in human adipose tissue involves capillary recruitment |
title_full |
GIP-induced vasodilation in human adipose tissue involves capillary recruitment |
title_fullStr |
GIP-induced vasodilation in human adipose tissue involves capillary recruitment |
title_full_unstemmed |
GIP-induced vasodilation in human adipose tissue involves capillary recruitment |
title_sort |
gip-induced vasodilation in human adipose tissue involves capillary recruitment |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2019-06-01 |
description |
Glucose-dependent insulinotropic polypeptide (GIP) in combination with hyperinsulinemia increase blood flow and triglyceride clearance in subcutaneous abdominal adipose tissue in lean humans. The present experiments were performed to determine whether the increase involves capillary recruitment. Eight lean healthy volunteers were studied before and after 1 h infusion of GIP or saline during a hyperglycemic–hyperinsulinemic clamp, raising plasma glucose and insulin to postprandial levels. Subcutaneous abdominal adipose tissue blood flow (ATBF) was measured by the 133Xenon clearance technique, and
microvascular blood volume was determined by contrast-enhanced ultrasound imaging.During infusion of saline and the clamp, both ATBF (2.7 ± 0.5 m L/min 100 g/tissue) and
microvascular blood volume remained unchanged throughout the experiments. During GIP infusion and the clamp, ATBF increased ~fourfold to 11.4 ± 1.9 mL/min 100 g/tissue, P < 0.001. Likewise, the contrast-enhanced ultrasound signal intensity, a measure of the microvascular blood volume, increased significantly 1 h after in fusion of GIP and the clamp (P = 0.003), but not in the control experiments. In conclusion, the increase in ATBF during GIP infusion involves recruitment of capillaries in healthy lean subjects, which probably increases the interaction of circulating lipoproteins with lipoprotein lipase, thus promoting adipose tissue lipid uptake. |
topic |
glucose dependent insulinotropic polypeptide adipose tissue blood flow ultrasonic imaging microcirculation |
url |
https://ec.bioscientifica.com/view/journals/ec/8/6/EC-19-0144.xml |
work_keys_str_mv |
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