Bone Density around Titanium Dental Implants Coating Tested/Coated with Chitosan or Melatonin: An Evaluation via Microtomography in Jaws of Beagle Dogs
Peri-implant bone density plays an important role in the osseointegration of dental implants. The aim of the study was to evaluate via micro-CT, in Hounsfield units, the bone density around dental implants coated with chitosan and melatonin and to compare it with the bone density around implants wit...
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doaj-d2b7f3f43b8f4814a4e9f15c94fa75f02021-07-23T13:36:01ZengMDPI AGCoatings2079-64122021-06-011177777710.3390/coatings11070777Bone Density around Titanium Dental Implants Coating Tested/Coated with Chitosan or Melatonin: An Evaluation via Microtomography in Jaws of Beagle DogsNansi López-Valverde0Antonio López-Valverde1Juan Manuel Aragoneses2Francisco Martínez-Martínez3María C. González-Escudero4Juan Manuel Ramírez5Department of Surgery, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, SpainDepartment of Surgery, Instituto de Investigación Biomédica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, SpainDean of The Faculty of Dentistry, Universidad Alfonso X El Sabio, 28691 Madrid, SpainOrthopaedic and Trauma Service, Virgen de la Arrixaca University Hospital, El Palmar, 30120 Murcia, SpainFaculty of Health Sciences, Universidad Católica San Antonio de Murcia (UCAM), 30107 Murcia, SpainDepartment of Morphological Sciences, University of Cordoba, Avenida Menéndez Pidal s/n, 14071, 14004 Cordoba, SpainPeri-implant bone density plays an important role in the osseointegration of dental implants. The aim of the study was to evaluate via micro-CT, in Hounsfield units, the bone density around dental implants coated with chitosan and melatonin and to compare it with the bone density around implants with a conventional etched surface after 12 weeks of immediate post-extraction placement in the jaws of Beagle dogs. Six dogs were used, and 48 implants were randomly placed: three groups—melatonin, chitosan, and control. Seven 10 mm × 10 mm regions of interest were defined in each implant (2 in the crestal zone, 4 in the medial zone, and 1 in the apical zone). A total of 336 sites were studied with the AMIDE tool, using the Norton and Gamble classification to assess bone density. The effect on bone density of surface coating variables (chitosan, melatonin, and control) at the crestal, medial, and apical sites and the implant positions (P2, P3, P4, and M1) was analyzed at bivariate and multivariate levels (linear regression). Adjusted effects on bone density did not indicate statistical significance for surface coatings (<i>p</i> = 0.653) but did for different levels of ROIs (<i>p</i> < 0.001) and for positions of the implants (<i>p</i> = 0.032). Micro-CT, with appropriate software, proved to be a powerful tool for measuring osseointegration.https://www.mdpi.com/2079-6412/11/7/777titanium dental implantschitosan coatingmelatonin coatingbone densityHounsfield unitymicro-computed tomography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nansi López-Valverde Antonio López-Valverde Juan Manuel Aragoneses Francisco Martínez-Martínez María C. González-Escudero Juan Manuel Ramírez |
spellingShingle |
Nansi López-Valverde Antonio López-Valverde Juan Manuel Aragoneses Francisco Martínez-Martínez María C. González-Escudero Juan Manuel Ramírez Bone Density around Titanium Dental Implants Coating Tested/Coated with Chitosan or Melatonin: An Evaluation via Microtomography in Jaws of Beagle Dogs Coatings titanium dental implants chitosan coating melatonin coating bone density Hounsfield unity micro-computed tomography |
author_facet |
Nansi López-Valverde Antonio López-Valverde Juan Manuel Aragoneses Francisco Martínez-Martínez María C. González-Escudero Juan Manuel Ramírez |
author_sort |
Nansi López-Valverde |
title |
Bone Density around Titanium Dental Implants Coating Tested/Coated with Chitosan or Melatonin: An Evaluation via Microtomography in Jaws of Beagle Dogs |
title_short |
Bone Density around Titanium Dental Implants Coating Tested/Coated with Chitosan or Melatonin: An Evaluation via Microtomography in Jaws of Beagle Dogs |
title_full |
Bone Density around Titanium Dental Implants Coating Tested/Coated with Chitosan or Melatonin: An Evaluation via Microtomography in Jaws of Beagle Dogs |
title_fullStr |
Bone Density around Titanium Dental Implants Coating Tested/Coated with Chitosan or Melatonin: An Evaluation via Microtomography in Jaws of Beagle Dogs |
title_full_unstemmed |
Bone Density around Titanium Dental Implants Coating Tested/Coated with Chitosan or Melatonin: An Evaluation via Microtomography in Jaws of Beagle Dogs |
title_sort |
bone density around titanium dental implants coating tested/coated with chitosan or melatonin: an evaluation via microtomography in jaws of beagle dogs |
publisher |
MDPI AG |
series |
Coatings |
issn |
2079-6412 |
publishDate |
2021-06-01 |
description |
Peri-implant bone density plays an important role in the osseointegration of dental implants. The aim of the study was to evaluate via micro-CT, in Hounsfield units, the bone density around dental implants coated with chitosan and melatonin and to compare it with the bone density around implants with a conventional etched surface after 12 weeks of immediate post-extraction placement in the jaws of Beagle dogs. Six dogs were used, and 48 implants were randomly placed: three groups—melatonin, chitosan, and control. Seven 10 mm × 10 mm regions of interest were defined in each implant (2 in the crestal zone, 4 in the medial zone, and 1 in the apical zone). A total of 336 sites were studied with the AMIDE tool, using the Norton and Gamble classification to assess bone density. The effect on bone density of surface coating variables (chitosan, melatonin, and control) at the crestal, medial, and apical sites and the implant positions (P2, P3, P4, and M1) was analyzed at bivariate and multivariate levels (linear regression). Adjusted effects on bone density did not indicate statistical significance for surface coatings (<i>p</i> = 0.653) but did for different levels of ROIs (<i>p</i> < 0.001) and for positions of the implants (<i>p</i> = 0.032). Micro-CT, with appropriate software, proved to be a powerful tool for measuring osseointegration. |
topic |
titanium dental implants chitosan coating melatonin coating bone density Hounsfield unity micro-computed tomography |
url |
https://www.mdpi.com/2079-6412/11/7/777 |
work_keys_str_mv |
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