A multiscale computational model of spatially resolved calcium cycling in cardiac myocytes: from detailed cleft dynamics to the whole cell concentration profiles

A multiscale computational model of spatially resolved calcium cycling in cardiac myocytes: from detailed cleft dynamics to the whole cell concentration profiles

Mathematical modelling of excitation-contraction coupling (ECC) in ventricular cardiac myocytes is a multiscale problem, and it is therefore difficult to develop spatially detailed simulation tools. ECC involves gradients on the length scale of 100 nm in dyadic spaces and concentration profiles alon...

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Bibliographic Details
Main Authors: Janine eVierheller, Wilhelm eNeubert, Martin eFalcke, Stephen Henry Gilbert, Nagaiah eChamakuri
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Physiology
Subjects:
cardiomyocyte
calcium cycling
FEM
Dyad
stochastic spatially resolved cell models
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00255/full

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