Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative
Abstract Background In recent years, human microbiota, especially gut microbiota, have emerged as an important yet complex trait influencing human metabolism, immunology, and diseases. Many studies are investigating the forces underlying the observed variation, including the human genetic variants t...
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2018-06-01
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Online Access: | http://link.springer.com/article/10.1186/s40168-018-0479-3 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun Wang Alexander Kurilshikov Djawad Radjabzadeh Williams Turpin Kenneth Croitoru Marc Jan Bonder Matthew A. Jackson Carolina Medina-Gomez Fabian Frost Georg Homuth Malte Rühlemann David Hughes Han-na Kim MiBioGen Consortium Initiative Tim D. Spector Jordana T. Bell Claire J. Steves Nicolas Timpson Andre Franke Cisca Wijmenga Katie Meyer Tim Kacprowski Lude Franke Andrew D. Paterson Jeroen Raes Robert Kraaij Alexandra Zhernakova |
spellingShingle |
Jun Wang Alexander Kurilshikov Djawad Radjabzadeh Williams Turpin Kenneth Croitoru Marc Jan Bonder Matthew A. Jackson Carolina Medina-Gomez Fabian Frost Georg Homuth Malte Rühlemann David Hughes Han-na Kim MiBioGen Consortium Initiative Tim D. Spector Jordana T. Bell Claire J. Steves Nicolas Timpson Andre Franke Cisca Wijmenga Katie Meyer Tim Kacprowski Lude Franke Andrew D. Paterson Jeroen Raes Robert Kraaij Alexandra Zhernakova Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative Microbiome Gut microbiome Genome-wide association studies (GWAS) Meta-analysis |
author_facet |
Jun Wang Alexander Kurilshikov Djawad Radjabzadeh Williams Turpin Kenneth Croitoru Marc Jan Bonder Matthew A. Jackson Carolina Medina-Gomez Fabian Frost Georg Homuth Malte Rühlemann David Hughes Han-na Kim MiBioGen Consortium Initiative Tim D. Spector Jordana T. Bell Claire J. Steves Nicolas Timpson Andre Franke Cisca Wijmenga Katie Meyer Tim Kacprowski Lude Franke Andrew D. Paterson Jeroen Raes Robert Kraaij Alexandra Zhernakova |
author_sort |
Jun Wang |
title |
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative |
title_short |
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative |
title_full |
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative |
title_fullStr |
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative |
title_full_unstemmed |
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative |
title_sort |
meta-analysis of human genome-microbiome association studies: the mibiogen consortium initiative |
publisher |
BMC |
series |
Microbiome |
issn |
2049-2618 |
publishDate |
2018-06-01 |
description |
Abstract Background In recent years, human microbiota, especially gut microbiota, have emerged as an important yet complex trait influencing human metabolism, immunology, and diseases. Many studies are investigating the forces underlying the observed variation, including the human genetic variants that shape human microbiota. Several preliminary genome-wide association studies (GWAS) have been completed, but more are necessary to achieve a fuller picture. Results Here, we announce the MiBioGen consortium initiative, which has assembled 18 population-level cohorts and some 19,000 participants. Its aim is to generate new knowledge for the rapidly developing field of microbiota research. Each cohort has surveyed the gut microbiome via 16S rRNA sequencing and genotyped their participants with full-genome SNP arrays. We have standardized the analytical pipelines for both the microbiota phenotypes and genotypes, and all the data have been processed using identical approaches. Our analysis of microbiome composition shows that we can reduce the potential artifacts introduced by technical differences in generating microbiota data. We are now in the process of benchmarking the association tests and performing meta-analyses of genome-wide associations. All pipeline and summary statistics results will be shared using public data repositories. Conclusion We present the largest consortium to date devoted to microbiota-GWAS. We have adapted our analytical pipelines to suit multi-cohort analyses and expect to gain insight into host-microbiota cross-talk at the genome-wide level. And, as an open consortium, we invite more cohorts to join us (by contacting one of the corresponding authors) and to follow the analytical pipeline we have developed. |
topic |
Gut microbiome Genome-wide association studies (GWAS) Meta-analysis |
url |
http://link.springer.com/article/10.1186/s40168-018-0479-3 |
work_keys_str_mv |
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doaj-d2dc4728dec94d99bf2a2a42195e7b7f2020-11-25T01:42:52ZengBMCMicrobiome2049-26182018-06-01611710.1186/s40168-018-0479-3Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiativeJun Wang0Alexander Kurilshikov1Djawad Radjabzadeh2Williams Turpin3Kenneth Croitoru4Marc Jan Bonder5Matthew A. Jackson6Carolina Medina-Gomez7Fabian Frost8Georg Homuth9Malte Rühlemann10David Hughes11Han-na Kim12MiBioGen Consortium InitiativeTim D. Spector13Jordana T. Bell14Claire J. Steves15Nicolas Timpson16Andre Franke17Cisca Wijmenga18Katie Meyer19Tim Kacprowski20Lude Franke21Andrew D. Paterson22Jeroen Raes23Robert Kraaij24Alexandra Zhernakova25CAS Key Laboratory for Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesDepartment of Genetics, University of Groningen, University Medical Center GroningenDepartment of Internal Medicine, Erasmus Medical CenterDivision of Gastroenterology, Department of Medicine, University of TorontoZane Cohen Centre for Digestive Diseases, Mount Sinai HospitalDepartment of Genetics, University of Groningen, University Medical Center GroningenDepartment of Twin Research and Genetic Epidemiology, King’s College LondonDepartment of Internal Medicine, Erasmus Medical CenterDepartment of Medicine A, University Medicine GreifswaldDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine GreifswaldInstitute of Clinical Molecular Biology, Christian Albrechts University of KielMRC Integrative Epidemiology Unit at University of BristolDepartment of Biochemistry, School of Medicine, Ewha Womans UniversityDepartment of Twin Research and Genetic Epidemiology, King’s College LondonDepartment of Twin Research and Genetic Epidemiology, King’s College LondonDepartment of Twin Research and Genetic Epidemiology, King’s College LondonMRC Integrative Epidemiology Unit at University of BristolInstitute of Clinical Molecular Biology, Christian Albrechts University of KielDepartment of Genetics, University of Groningen, University Medical Center GroningenDepartment of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel HillDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine GreifswaldDepartment of Genetics, University of Groningen, University Medical Center GroningenDivision of Biostatistics, Dalla Lana School of Public Health, University of TorontoDepartment of Microbiology and Immunology, Rega Institute. KU Leuven – University of LeuvenDepartment of Internal Medicine, Erasmus Medical CenterDepartment of Genetics, University of Groningen, University Medical Center GroningenAbstract Background In recent years, human microbiota, especially gut microbiota, have emerged as an important yet complex trait influencing human metabolism, immunology, and diseases. Many studies are investigating the forces underlying the observed variation, including the human genetic variants that shape human microbiota. Several preliminary genome-wide association studies (GWAS) have been completed, but more are necessary to achieve a fuller picture. Results Here, we announce the MiBioGen consortium initiative, which has assembled 18 population-level cohorts and some 19,000 participants. Its aim is to generate new knowledge for the rapidly developing field of microbiota research. Each cohort has surveyed the gut microbiome via 16S rRNA sequencing and genotyped their participants with full-genome SNP arrays. We have standardized the analytical pipelines for both the microbiota phenotypes and genotypes, and all the data have been processed using identical approaches. Our analysis of microbiome composition shows that we can reduce the potential artifacts introduced by technical differences in generating microbiota data. We are now in the process of benchmarking the association tests and performing meta-analyses of genome-wide associations. All pipeline and summary statistics results will be shared using public data repositories. Conclusion We present the largest consortium to date devoted to microbiota-GWAS. We have adapted our analytical pipelines to suit multi-cohort analyses and expect to gain insight into host-microbiota cross-talk at the genome-wide level. And, as an open consortium, we invite more cohorts to join us (by contacting one of the corresponding authors) and to follow the analytical pipeline we have developed.http://link.springer.com/article/10.1186/s40168-018-0479-3Gut microbiomeGenome-wide association studies (GWAS)Meta-analysis |