Mathematical Models of Cardiac Pacemaking Function
Over the past half century, there has been intense and fruitful interaction between experimental and computational investigations of cardiac function. This interaction has, for example, led to deep understanding of cardiac excitation-contraction coupling; how it works, as well as how it fails. Howev...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2013-10-01
|
Series: | Frontiers in Physics |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphy.2013.00020/full |
id |
doaj-d2f146148106470ea3205f563a53e70e |
---|---|
record_format |
Article |
spelling |
doaj-d2f146148106470ea3205f563a53e70e2020-11-24T22:54:20ZengFrontiers Media S.A.Frontiers in Physics2296-424X2013-10-01110.3389/fphy.2013.0002066458Mathematical Models of Cardiac Pacemaking FunctionPan eLi0Glenn T. Lines1Mary M. Maleckar2Aslak eTveito3Simula Research LaboratorySimula Research LaboratorySimula Research LaboratorySimula Research LaboratoryOver the past half century, there has been intense and fruitful interaction between experimental and computational investigations of cardiac function. This interaction has, for example, led to deep understanding of cardiac excitation-contraction coupling; how it works, as well as how it fails. However, many lines of inquiry remain unresolved, among them the initiation of each heartbeat. The sinoatrial node, a cluster of specialized pacemaking cells in the right atrium of the heart, spontaneously generates an electro-chemical wave that spreads through the atria and through the cardiac conduction system to the ventricles, initiating the contraction of cardiac muscle essential for pumping blood to the body. Despite the fundamental importance of this primary pacemaker, this process is still not fully understood, and ionic mechanisms underlying cardiac pacemaking function are currently under heated debate. Several mathematical models of sinoatrial node cell membrane electrophysiology have been constructed as based on different experimental data sets and hypotheses. As could be expected, these differing models offer diverse predictions about cardiac pacemaking activities. This paper aims to present the current state of debate over the origins of the pacemaking function of the sinoatrial node. Here, we will specifically review the state-of-the-art of cardiac pacemaker modeling, with a special emphasis on current discrepancies, limitations, and future challenges.http://journal.frontiersin.org/Journal/10.3389/fphy.2013.00020/fullElectrophysiologyIon Channelsmathematical modelingpacemakercardiac automaticity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pan eLi Glenn T. Lines Mary M. Maleckar Aslak eTveito |
spellingShingle |
Pan eLi Glenn T. Lines Mary M. Maleckar Aslak eTveito Mathematical Models of Cardiac Pacemaking Function Frontiers in Physics Electrophysiology Ion Channels mathematical modeling pacemaker cardiac automaticity |
author_facet |
Pan eLi Glenn T. Lines Mary M. Maleckar Aslak eTveito |
author_sort |
Pan eLi |
title |
Mathematical Models of Cardiac Pacemaking Function |
title_short |
Mathematical Models of Cardiac Pacemaking Function |
title_full |
Mathematical Models of Cardiac Pacemaking Function |
title_fullStr |
Mathematical Models of Cardiac Pacemaking Function |
title_full_unstemmed |
Mathematical Models of Cardiac Pacemaking Function |
title_sort |
mathematical models of cardiac pacemaking function |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physics |
issn |
2296-424X |
publishDate |
2013-10-01 |
description |
Over the past half century, there has been intense and fruitful interaction between experimental and computational investigations of cardiac function. This interaction has, for example, led to deep understanding of cardiac excitation-contraction coupling; how it works, as well as how it fails. However, many lines of inquiry remain unresolved, among them the initiation of each heartbeat. The sinoatrial node, a cluster of specialized pacemaking cells in the right atrium of the heart, spontaneously generates an electro-chemical wave that spreads through the atria and through the cardiac conduction system to the ventricles, initiating the contraction of cardiac muscle essential for pumping blood to the body. Despite the fundamental importance of this primary pacemaker, this process is still not fully understood, and ionic mechanisms underlying cardiac pacemaking function are currently under heated debate. Several mathematical models of sinoatrial node cell membrane electrophysiology have been constructed as based on different experimental data sets and hypotheses. As could be expected, these differing models offer diverse predictions about cardiac pacemaking activities. This paper aims to present the current state of debate over the origins of the pacemaking function of the sinoatrial node. Here, we will specifically review the state-of-the-art of cardiac pacemaker modeling, with a special emphasis on current discrepancies, limitations, and future challenges. |
topic |
Electrophysiology Ion Channels mathematical modeling pacemaker cardiac automaticity |
url |
http://journal.frontiersin.org/Journal/10.3389/fphy.2013.00020/full |
work_keys_str_mv |
AT paneli mathematicalmodelsofcardiacpacemakingfunction AT glenntlines mathematicalmodelsofcardiacpacemakingfunction AT marymmaleckar mathematicalmodelsofcardiacpacemakingfunction AT aslaketveito mathematicalmodelsofcardiacpacemakingfunction |
_version_ |
1725660614866501632 |