Allergic TH2 Response Governed by B-Cell Lymphoma 6 Function in Naturally Occurring Memory Phenotype CD4+ T Cells

Allergic TH2 Response Governed by B-Cell Lymphoma 6 Function in Naturally Occurring Memory Phenotype CD4+ T Cells

Transcriptional repressor B-cell lymphoma 6 (Bcl6) appears to regulate TH2 immune responses in allergies, but its precise role is unclear. We previously reported that Bcl6 suppressed IL-4 production in naïve CD4+ T cell-derived memory TH2 cells. To investigate Bcl6 function in allergic responses in...

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Bibliographic Details
Main Authors: Takashi Ogasawara, Yuko Kohashi, Jun Ikari, Toshibumi Taniguchi, Nobuhide Tsuruoka, Haruko Watanabe-Takano, Lisa Fujimura, Akemi Sakamoto, Masahiko Hatano, Hirokuni Hirata, Yasutsugu Fukushima, Takeshi Fukuda, Kazuhiro Kurasawa, Koichiro Tatsumi, Takeshi Tokuhisa, Masafumi Arima
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
B-cell lymphoma 6
naturally occurring memory phenotype T cells
allergy
TH2 cells
asthma
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00750/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00750/full

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