Analysis on the clinical effect and visual acuity prognostic factors of BRVO-ME treated with Ranibizumab
AIM:To evaluate the functional and structural changes of foveal macula after intravitreal ranibizumab injection in patients with macular edema secondary to branch retinal vein occlusion(BRVO-ME)and screen the factors that can predict the final visual acuity of the patients. <p>METHODS: Prospec...
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doaj-d2fd8a29a2cc4810af2f28cca20605fc2020-11-25T01:39:23ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232020-04-0120467367910.3980/j.issn.1672-5123.2020.4.21Analysis on the clinical effect and visual acuity prognostic factors of BRVO-ME treated with RanibizumabJing Yang0Yue-Ling Zhang1Na Yang2Zhao-Hui Gu3Li-Ying Wang4Dong-Yan Wang5Graduate School, Chengde Medical University, Chengde 067000, Hebei Province, ChinaSecond Department of Ophthalmology, Baoding No.1 Central Hospital, Baoding 067000, Hebei Province, ChinaSecond Department of Ophthalmology, Baoding No.1 Central Hospital, Baoding 067000, Hebei Province, ChinaSecond Department of Ophthalmology, Baoding No.1 Central Hospital, Baoding 067000, Hebei Province, ChinaSecond Department of Ophthalmology, Baoding No.1 Central Hospital, Baoding 067000, Hebei Province, ChinaSecond Department of Ophthalmology, Baoding No.1 Central Hospital, Baoding 067000, Hebei Province, ChinaAIM:To evaluate the functional and structural changes of foveal macula after intravitreal ranibizumab injection in patients with macular edema secondary to branch retinal vein occlusion(BRVO-ME)and screen the factors that can predict the final visual acuity of the patients. <p>METHODS: Prospective, clinical study. In this prospective single-arm study, we observed 25 patients(25 eyes)diagnosed with BRVO-ME who were enrolled from 2018.6-2019.5 in the first central hospital of Baoding. All patients received monthly ranibizumab 0.5mg injections for 3 consecutive months. The best-corrected visual acuity(BCVA),the central macular thickness(CMT)and the vessel perfusion density(VPD), vessel length density(VLD)and fovea avascular zone(FAZ)of superficial capillary plexus(SCP)were evaluated detected by optical coherence tomography(OCT and OCTA)before and 1mo after the third injection. Mf-ERG was used to analyze the amplitude density of P1 wave and latency of P1, N1 wave from ring 1 and ring 2. <p>RESULTS: After treatment, BCVA(LogMAR)was improved significantly compared with that before(0.323±0.086 <i>vs</i> 0.773±0.304, <i>P</i><0.05). CMT was lower than before(239.385±33.175μm <i>vs</i> 489.346±137.453μm, <i>P</i><0.05), but there was no significant change in FAZ, VPD and VLD of SCP within 6mm×6mm of macular area before and after treatment(<i>P</i>>0.05). The latency of P1, N1 wave of ring 1 and ring 2 were significantly decresed from baseline, while the amplitude density of P1 wave was increased(<i>P</i><0.05). Pearson correlation analysis shows that age, baseline BCVA, VLD, VPD, FAZ were significantly correlated with changes in visual acuity before and after treatment(<i>P</i><0.05).<p>CONCLUSION: In patients with BRVO-ME, ranibizumab therapy can reduce CMT, improve BCVA and improve the structure and function of macular area. Age, BCVA before treatment and microstructure parameters of macular area can be used as predictors of vision improvement.http://ies.ijo.cn/cn_publish/2020/4/202004021.pdfbranch retinal vein occlusionanti-vegf therapyoptical coherence tomography angiographymultifocal electroretinogram |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Yang Yue-Ling Zhang Na Yang Zhao-Hui Gu Li-Ying Wang Dong-Yan Wang |
spellingShingle |
Jing Yang Yue-Ling Zhang Na Yang Zhao-Hui Gu Li-Ying Wang Dong-Yan Wang Analysis on the clinical effect and visual acuity prognostic factors of BRVO-ME treated with Ranibizumab Guoji Yanke Zazhi branch retinal vein occlusion anti-vegf therapy optical coherence tomography angiography multifocal electroretinogram |
author_facet |
Jing Yang Yue-Ling Zhang Na Yang Zhao-Hui Gu Li-Ying Wang Dong-Yan Wang |
author_sort |
Jing Yang |
title |
Analysis on the clinical effect and visual acuity prognostic factors of BRVO-ME treated with Ranibizumab |
title_short |
Analysis on the clinical effect and visual acuity prognostic factors of BRVO-ME treated with Ranibizumab |
title_full |
Analysis on the clinical effect and visual acuity prognostic factors of BRVO-ME treated with Ranibizumab |
title_fullStr |
Analysis on the clinical effect and visual acuity prognostic factors of BRVO-ME treated with Ranibizumab |
title_full_unstemmed |
Analysis on the clinical effect and visual acuity prognostic factors of BRVO-ME treated with Ranibizumab |
title_sort |
analysis on the clinical effect and visual acuity prognostic factors of brvo-me treated with ranibizumab |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
Guoji Yanke Zazhi |
issn |
1672-5123 1672-5123 |
publishDate |
2020-04-01 |
description |
AIM:To evaluate the functional and structural changes of foveal macula after intravitreal ranibizumab injection in patients with macular edema secondary to branch retinal vein occlusion(BRVO-ME)and screen the factors that can predict the final visual acuity of the patients. <p>METHODS: Prospective, clinical study. In this prospective single-arm study, we observed 25 patients(25 eyes)diagnosed with BRVO-ME who were enrolled from 2018.6-2019.5 in the first central hospital of Baoding. All patients received monthly ranibizumab 0.5mg injections for 3 consecutive months. The best-corrected visual acuity(BCVA),the central macular thickness(CMT)and the vessel perfusion density(VPD), vessel length density(VLD)and fovea avascular zone(FAZ)of superficial capillary plexus(SCP)were evaluated detected by optical coherence tomography(OCT and OCTA)before and 1mo after the third injection. Mf-ERG was used to analyze the amplitude density of P1 wave and latency of P1, N1 wave from ring 1 and ring 2. <p>RESULTS: After treatment, BCVA(LogMAR)was improved significantly compared with that before(0.323±0.086 <i>vs</i> 0.773±0.304, <i>P</i><0.05). CMT was lower than before(239.385±33.175μm <i>vs</i> 489.346±137.453μm, <i>P</i><0.05), but there was no significant change in FAZ, VPD and VLD of SCP within 6mm×6mm of macular area before and after treatment(<i>P</i>>0.05). The latency of P1, N1 wave of ring 1 and ring 2 were significantly decresed from baseline, while the amplitude density of P1 wave was increased(<i>P</i><0.05). Pearson correlation analysis shows that age, baseline BCVA, VLD, VPD, FAZ were significantly correlated with changes in visual acuity before and after treatment(<i>P</i><0.05).<p>CONCLUSION: In patients with BRVO-ME, ranibizumab therapy can reduce CMT, improve BCVA and improve the structure and function of macular area. Age, BCVA before treatment and microstructure parameters of macular area can be used as predictors of vision improvement. |
topic |
branch retinal vein occlusion anti-vegf therapy optical coherence tomography angiography multifocal electroretinogram |
url |
http://ies.ijo.cn/cn_publish/2020/4/202004021.pdf |
work_keys_str_mv |
AT jingyang analysisontheclinicaleffectandvisualacuityprognosticfactorsofbrvometreatedwithranibizumab AT yuelingzhang analysisontheclinicaleffectandvisualacuityprognosticfactorsofbrvometreatedwithranibizumab AT nayang analysisontheclinicaleffectandvisualacuityprognosticfactorsofbrvometreatedwithranibizumab AT zhaohuigu analysisontheclinicaleffectandvisualacuityprognosticfactorsofbrvometreatedwithranibizumab AT liyingwang analysisontheclinicaleffectandvisualacuityprognosticfactorsofbrvometreatedwithranibizumab AT dongyanwang analysisontheclinicaleffectandvisualacuityprognosticfactorsofbrvometreatedwithranibizumab |
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