Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment

Lysophospholipids (LPLs) are bioactive signaling lipids that are generated from phospholipase-mediated hydrolyzation of membrane phospholipids (PLs) and sphingolipids (SLs). Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are two of the best-characterized LPLs which mediate a variety o...

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Main Authors: Yining Hao, Min Guo, Yiwei Feng, Qiang Dong, Mei Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00058/full
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spelling doaj-d302e09714c74dcd9d09b8d6906b4e532020-11-25T01:45:56ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992020-04-011310.3389/fnmol.2020.00058529384Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological ImpairmentYining Hao0Min Guo1Yiwei Feng2Qiang Dong3Mei Cui4Department of Neurology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, ChinaDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, ChinaLysophospholipids (LPLs) are bioactive signaling lipids that are generated from phospholipase-mediated hydrolyzation of membrane phospholipids (PLs) and sphingolipids (SLs). Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are two of the best-characterized LPLs which mediate a variety of cellular physiological responses via specific G-protein coupled receptor (GPCR) mediated signaling pathways. Considerable evidence now demonstrates the crucial role of LPA and S1P in neurodegenerative diseases, especially in Alzheimer’s disease (AD). Dysfunction of LPA and S1P metabolism can lead to aberrant accumulation of amyloid-β (Aβ) peptides, the formation of neurofibrillary tangles (NFTs), neuroinflammation and ultimately neuronal death. Summarizing LPA and S1P signaling profile may aid in profound health and pathological processes. In the current review, we will introduce the metabolism as well as the physiological roles of LPA and S1P in maintaining the normal functions of the nervous system. Given these pivotal functions, we will further discuss the role of dysregulation of LPA and S1P in promoting AD pathogenesis.https://www.frontiersin.org/article/10.3389/fnmol.2020.00058/fulllysophospholipidslysophosphatidic acid (LPA)sphingosine-1-phosphate (S1P)G-protein coupled receptor (GPCR)Alzheimer’s disease (AD)
collection DOAJ
language English
format Article
sources DOAJ
author Yining Hao
Min Guo
Yiwei Feng
Qiang Dong
Mei Cui
spellingShingle Yining Hao
Min Guo
Yiwei Feng
Qiang Dong
Mei Cui
Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment
Frontiers in Molecular Neuroscience
lysophospholipids
lysophosphatidic acid (LPA)
sphingosine-1-phosphate (S1P)
G-protein coupled receptor (GPCR)
Alzheimer’s disease (AD)
author_facet Yining Hao
Min Guo
Yiwei Feng
Qiang Dong
Mei Cui
author_sort Yining Hao
title Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment
title_short Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment
title_full Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment
title_fullStr Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment
title_full_unstemmed Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment
title_sort lysophospholipids and their g-coupled protein signaling in alzheimer’s disease: from physiological performance to pathological impairment
publisher Frontiers Media S.A.
series Frontiers in Molecular Neuroscience
issn 1662-5099
publishDate 2020-04-01
description Lysophospholipids (LPLs) are bioactive signaling lipids that are generated from phospholipase-mediated hydrolyzation of membrane phospholipids (PLs) and sphingolipids (SLs). Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are two of the best-characterized LPLs which mediate a variety of cellular physiological responses via specific G-protein coupled receptor (GPCR) mediated signaling pathways. Considerable evidence now demonstrates the crucial role of LPA and S1P in neurodegenerative diseases, especially in Alzheimer’s disease (AD). Dysfunction of LPA and S1P metabolism can lead to aberrant accumulation of amyloid-β (Aβ) peptides, the formation of neurofibrillary tangles (NFTs), neuroinflammation and ultimately neuronal death. Summarizing LPA and S1P signaling profile may aid in profound health and pathological processes. In the current review, we will introduce the metabolism as well as the physiological roles of LPA and S1P in maintaining the normal functions of the nervous system. Given these pivotal functions, we will further discuss the role of dysregulation of LPA and S1P in promoting AD pathogenesis.
topic lysophospholipids
lysophosphatidic acid (LPA)
sphingosine-1-phosphate (S1P)
G-protein coupled receptor (GPCR)
Alzheimer’s disease (AD)
url https://www.frontiersin.org/article/10.3389/fnmol.2020.00058/full
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