Association of expression of ring finger protein 187 with tumor metastasis and clinical prognosis in hepatocellular carcinoma
Objective: To investigate the expression of RNF187 in hepatocellular carcinoma (HCC) and its relationship with prognosis. Methods: The mRNA and protein expressions in hepatocellular carcinoma and tumor-adjacent tissues of HCC patients were determined by qRT-PCR and Western blot analysis, and RNF1...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2020-10-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/202020/03.pdf |
Summary: | Objective: To investigate the expression of RNF187 in hepatocellular carcinoma (HCC)
and its relationship with prognosis. Methods: The mRNA and protein expressions in
hepatocellular carcinoma and tumor-adjacent tissues of HCC patients were determined by
qRT-PCR and Western blot analysis, and RNF187 expressions in HCC were detected by
immunohistochemistry. The relationship of RNF187 expression with clinicopathologic factors
and prognosis in HCC patients were analyzed. Results: RNF187 expressed highly in HCC
tissues compared with the corresponding adjacent liver tissues both in mRNA and protein
level, and significantly higher in HCC tissue from patients with intrahepatic metastases or
vascular invasion than those in HCC tissue from patients without intrahepatic metastases and
vascular invasion (all P<0.05). The 5-year survival rate of the high expression group was
lower than that of the low expression group (P<0.05). Cox regression analysis revealed that
high RNF187 expression was independent risk factor for postoperative survival (HR=1.313,
95% CI=1.128~1.537, P<0.001). Conclusion: High expression of RNF187 in HCC is closely
related to tumor prognosis, which may become a new index to evaluate the clinical diagnosis
and prognosis of liver cancer. |
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ISSN: | 1007-1237 1007-1237 |