Association of expression of ring finger protein 187 with tumor metastasis and clinical prognosis in hepatocellular carcinoma
Objective: To investigate the expression of RNF187 in hepatocellular carcinoma (HCC) and its relationship with prognosis. Methods: The mRNA and protein expressions in hepatocellular carcinoma and tumor-adjacent tissues of HCC patients were determined by qRT-PCR and Western blot analysis, and RNF1...
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doaj-d30d143082434cd4af538d3970fe392f2020-11-25T04:04:31ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372020-10-0126201216Association of expression of ring finger protein 187 with tumor metastasis and clinical prognosis in hepatocellular carcinomaRong Tang0Zhen-Sheng Zhang1Department of Hepatopancreatobiliary Surgery, Hainan Provinicial People's Hospital, Haikou 570311, ChinaDepartment of Hepatopancreatobiliary Surgery, Hainan Provinicial People's Hospital, Haikou 570311, ChinaObjective: To investigate the expression of RNF187 in hepatocellular carcinoma (HCC) and its relationship with prognosis. Methods: The mRNA and protein expressions in hepatocellular carcinoma and tumor-adjacent tissues of HCC patients were determined by qRT-PCR and Western blot analysis, and RNF187 expressions in HCC were detected by immunohistochemistry. The relationship of RNF187 expression with clinicopathologic factors and prognosis in HCC patients were analyzed. Results: RNF187 expressed highly in HCC tissues compared with the corresponding adjacent liver tissues both in mRNA and protein level, and significantly higher in HCC tissue from patients with intrahepatic metastases or vascular invasion than those in HCC tissue from patients without intrahepatic metastases and vascular invasion (all P<0.05). The 5-year survival rate of the high expression group was lower than that of the low expression group (P<0.05). Cox regression analysis revealed that high RNF187 expression was independent risk factor for postoperative survival (HR=1.313, 95% CI=1.128~1.537, P<0.001). Conclusion: High expression of RNF187 in HCC is closely related to tumor prognosis, which may become a new index to evaluate the clinical diagnosis and prognosis of liver cancer.http://www.hnykdxxb.com/PDF/202020/03.pdfhepatocellular carcinomarnf187clinicopathological featuresprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rong Tang Zhen-Sheng Zhang |
spellingShingle |
Rong Tang Zhen-Sheng Zhang Association of expression of ring finger protein 187 with tumor metastasis and clinical prognosis in hepatocellular carcinoma Journal of Hainan Medical University hepatocellular carcinoma rnf187 clinicopathological features prognosis |
author_facet |
Rong Tang Zhen-Sheng Zhang |
author_sort |
Rong Tang |
title |
Association of expression of ring finger protein 187 with tumor metastasis and clinical prognosis in hepatocellular carcinoma |
title_short |
Association of expression of ring finger protein 187 with tumor metastasis and clinical prognosis in hepatocellular carcinoma |
title_full |
Association of expression of ring finger protein 187 with tumor metastasis and clinical prognosis in hepatocellular carcinoma |
title_fullStr |
Association of expression of ring finger protein 187 with tumor metastasis and clinical prognosis in hepatocellular carcinoma |
title_full_unstemmed |
Association of expression of ring finger protein 187 with tumor metastasis and clinical prognosis in hepatocellular carcinoma |
title_sort |
association of expression of ring finger protein 187 with tumor metastasis and clinical prognosis in hepatocellular carcinoma |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2020-10-01 |
description |
Objective: To investigate the expression of RNF187 in hepatocellular carcinoma (HCC)
and its relationship with prognosis. Methods: The mRNA and protein expressions in
hepatocellular carcinoma and tumor-adjacent tissues of HCC patients were determined by
qRT-PCR and Western blot analysis, and RNF187 expressions in HCC were detected by
immunohistochemistry. The relationship of RNF187 expression with clinicopathologic factors
and prognosis in HCC patients were analyzed. Results: RNF187 expressed highly in HCC
tissues compared with the corresponding adjacent liver tissues both in mRNA and protein
level, and significantly higher in HCC tissue from patients with intrahepatic metastases or
vascular invasion than those in HCC tissue from patients without intrahepatic metastases and
vascular invasion (all P<0.05). The 5-year survival rate of the high expression group was
lower than that of the low expression group (P<0.05). Cox regression analysis revealed that
high RNF187 expression was independent risk factor for postoperative survival (HR=1.313,
95% CI=1.128~1.537, P<0.001). Conclusion: High expression of RNF187 in HCC is closely
related to tumor prognosis, which may become a new index to evaluate the clinical diagnosis
and prognosis of liver cancer. |
topic |
hepatocellular carcinoma rnf187 clinicopathological features prognosis |
url |
http://www.hnykdxxb.com/PDF/202020/03.pdf |
work_keys_str_mv |
AT rongtang associationofexpressionofringfingerprotein187withtumormetastasisandclinicalprognosisinhepatocellularcarcinoma AT zhenshengzhang associationofexpressionofringfingerprotein187withtumormetastasisandclinicalprognosisinhepatocellularcarcinoma |
_version_ |
1724436341536587776 |