Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells

Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells

Purpose: The activation of ROS-NLRP3-IL-1β signaling axis induced by hyperosmotic stress (HS) has been recognized as a key priming stage of epithelial inflammation in dry eye pathogenesis. The current study aims to investigate whether calcitriol, the active metabolite of vitamin D3, could protect ce...

Full description

Bibliographic Details
Main Authors:	Yiqin Dai, Jing Zhang, Jun Xiang, Yue Li, Dan Wu, Jianjiang Xu
Format:	Article
Language:	English
Published:	Elsevier 2019-02-01
Series:	Redox Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231718309248

Similar Items

Calcitriol Alleviates Hyperosmotic Stress-Induced Corneal Epithelial Cell Damage via Inhibiting the NLRP3–ASC–Caspase-1–GSDMD Pyroptosis Pathway in Dry Eye Disease
by: Zhang J, et al.
Published: (2021-07-01)

Effects of Lutein on Hyperosmoticity-Induced Upregulation of IL-6 in Cultured Corneal Epithelial Cells and Its Relevant Signal Pathways
by: Shih-Chun Chao, et al.
Published: (2016-01-01)

Nerve growth factor inhibits TLR3-induced inflammatory cascades in human corneal epithelial cells
by: Huiyu Chen, et al.
Published: (2019-12-01)

Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism
by: Changmeng Cui, et al.
Published: (2021-09-01)

Genistein‐Calcitriol Mitigates Hyperosmotic Stress‐Induced TonEBP, CFTR Dysfunction, VDR Degradation and Inflammation in Dry Eye Disease
by: Trailokyanath Panigrahi, et al.
Published: (2021-01-01)

Different Effects of Pro‐Inflammatory Factors and Hyperosmotic Stress on Corneal Epithelial Stem/Progenitor Cells and Wound Healing in Mice
by: Lingling Yang, et al.
Published: (2019-01-01)

Efficacy of hyperosmotic glucose in treatment of corneal edema after cataract surgery
by: Yu-Mei Shao, et al.
Published: (2015-02-01)

Basic Properties of the p38 Signaling Pathway in Response to Hyperosmotic Shock.
by: Nabil Ben Messaoud, et al.
Published: (2015-01-01)

Cytosolic acidification as a signal mediating hyperosmotic stress responses in <it>Dictyostelium discoideum</it>
by: Klein Gérard, et al.
Published: (2001-06-01)

Checkpoints in a yeast differentiation pathway coordinate signaling during hyperosmotic stress.
by: Michal J Nagiec, et al.
Published: (2012-01-01)

Calcitriol transmembrane signalling: regulation of rat muscle phospholipase D activity
by: Maria Marta Facchinetti, et al.
Published: (1998-01-01)

The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis
by: Pengfei Liu, et al.
Published: (2021-01-01)

Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis
by: Zhuming Chen, et al.
Published: (2019-12-01)

Insights into a Novel Signaling Pathway that Determines Cell Fate in Response to Hyperosmotic Stress
by: Farabaugh, Kenneth Thomas, kt
Published: (2019)

Sweet Taste Receptors Mediated ROS-NLRP3 Inflammasome Signaling Activation: Implications for Diabetic Nephropathy
by: Luping Zhou, et al.
Published: (2018-01-01)

Cr (VI) induces abnormalities in glucose and lipid metabolism through ROS/Nrf2 signaling
by: Xiaohong Li, et al.
Published: (2021-08-01)

Koumine Suppresses IL-1β Secretion and Attenuates Inflammation Associated With Blocking ROS/NF-κB/NLRP3 Axis in Macrophages
by: Yufei Luo, et al.
Published: (2021-01-01)

GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells
by: Dawid Krokowski, et al.
Published: (2017-12-01)

ROS and ROS-Mediated Cellular Signaling
by: Jixiang Zhang, et al.
Published: (2016-01-01)

Glycine Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Regulating NLRP3 Inflammasome and NRF2 Signaling
by: Yunchang Zhang, et al.
Published: (2020-02-01)

Effect of Tripterygium wilfordii Polycoride on the NOXs-ROS-NLRP3 Inflammasome Signaling Pathway in Mice with Ulcerative Colitis
by: Ma Fangxiao, et al.
Published: (2019-01-01)

PCB118 Induces Inflammation of Islet Beta Cells via Activating ROS-NLRP3 Inflammasome Signaling
by: Chunxia Jiang, et al.
Published: (2021-01-01)

The Antioxidative Action of ZTP by Increasing Nrf2/ARE Signal Pathway
by: Liang Yang, et al.
Published: (2019-01-01)

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling
by: Ye Yu, et al.
Published: (2020-12-01)

The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases
by: Xueyan Zhang, et al.
Published: (2020-01-01)

Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in the Patched Mouse Model of Embryonal Rhabdomyosarcoma
by: Anja Uhmann, et al.
Published: (2012-01-01)

AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway
by: Ming Zhang, et al.
Published: (2019-01-01)

RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose
by: Chenlin Gao, et al.
Published: (2019-01-01)

Identification of regulators and effectors of RhoGTPase signalling in corneal epithelial cells
by: Terry, S. J.
Published: (2011)

Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer
by: Jin-Feng Teng, et al.
Published: (2020-01-01)

Interplay between NO Signalling, ROS, and the Antioxidant System in Plants
Published: (2017)

The role of vitamin D3 in signaling pathways – potential anticancer properties of calcitriol and its analogues
by: Olga Wiecheć
Published: (2019-12-01)

Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling
by: Yuqing Lin, et al.
Published: (2020-12-01)

Myeloid Nrf2 deficiency aggravates non-alcoholic steatohepatitis progression by regulating YAP-mediated NLRP3 inflammasome signaling
by: Peng Wang, et al.
Published: (2021-05-01)

Crizotinib and Sunitinib Induce Hepatotoxicity and Mitochondrial Apoptosis in L02 Cells via ROS and Nrf2 Signaling Pathway
by: Lin Guo, et al.
Published: (2021-02-01)

Tabersonine ameliorates osteoblast apoptosis in rats with dexamethasone-induced osteoporosis by regulating the Nrf2/ROS/Bax signalling pathway
by: Xi Sun, et al.
Published: (2020-09-01)

Oridonin-Loaded Nanoparticles Inhibit Breast Cancer Progression Through Regulation of ROS-Related Nrf2 Signaling Pathway
by: Yue Zhao, et al.
Published: (2021-04-01)

Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress
by: Alexander Muir, et al.
Published: (2015-08-01)

Substance P Inhibits Hyperosmotic Stress-Induced Apoptosis in Corneal Epithelial Cells through the Mechanism of Akt Activation and Reactive Oxygen Species Scavenging via the Neurokinin-1 Receptor.
by: Lingling Yang, et al.
Published: (2016-01-01)

Uric acid regulates NLRP3/IL-1β signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux
by: Wei Yin, et al.
Published: (2019-08-01)

Cannot write session to /tmp/vufind_sessions/sess_9a3qbgu8sn7dcpm8du5jht6hv4