Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model

Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model

The IL-2/IL-2Ralpha (CD25) axis is of central importance for the interplay of effector and regulatory T cells. Nevertheless, the question how different antigen loads are translated into appropriate IL-2 production to ensure adequate responses against pathogens remains largely unexplored. Here we fin...

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Bibliographic Details
Main Authors: Franziska Fuhrmann, Timo Lischke, Fridolin Gross, Tobias Scheel, Laura Bauer, Khalid Wasim Kalim, Andreas Radbruch, Hanspeter Herzel, Andreas Hutloff, Ria Baumgrass
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
adaptive immune response
Th cell activation
TCR signaling
cytokine expression
systems biology
reaction-diffusion model
Online Access:https://elifesciences.org/articles/20616

Internet

https://elifesciences.org/articles/20616

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