Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study
Objectives. Our aim was to determine the risk of diabetes among osteoarthritis (OA) cases in a prospective longitudinal study. Methods. Administrative health records of 577,601 randomly selected individuals from British Columbia, Canada, from 1991 to 2009, were analyzed. OA and diabetes cases were i...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2014-01-01
|
Series: | International Journal of Rheumatology |
Online Access: | http://dx.doi.org/10.1155/2014/620920 |
id |
doaj-d31d7b9d6ab84e5f86a68cbfc0701398 |
---|---|
record_format |
Article |
spelling |
doaj-d31d7b9d6ab84e5f86a68cbfc07013982020-11-24T23:47:26ZengHindawi LimitedInternational Journal of Rheumatology1687-92601687-92792014-01-01201410.1155/2014/620920620920Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal StudyM. Mushfiqur Rahman0Jolanda Cibere1Aslam H. Anis2Charlie H. Goldsmith3Jacek A. Kopec4School of Population and Public Health, University of British Columbia, Vancouver, BC, V6T 1Z3, CanadaDepartment of Medicine, University of British Columbia, Vancouver, BC, V5Z 1M9, CanadaSchool of Population and Public Health, University of British Columbia, Vancouver, BC, V6T 1Z3, CanadaArthritis Research Centre of Canada, 5591 No. 3 Road, Richmond, BC, V6X 2C7, CanadaSchool of Population and Public Health, University of British Columbia, Vancouver, BC, V6T 1Z3, CanadaObjectives. Our aim was to determine the risk of diabetes among osteoarthritis (OA) cases in a prospective longitudinal study. Methods. Administrative health records of 577,601 randomly selected individuals from British Columbia, Canada, from 1991 to 2009, were analyzed. OA and diabetes cases were identified by checking physician’s visits and hospital records. From 1991 to 1996 we documented 19,143 existing OA cases and selected one non-OA individual matched by age, sex, and year of administrative records. Poisson regression and Cox proportional hazards models were fitted to estimate the effects after adjusting for available sociodemographic and medical factors. Results. At baseline, the mean age of OA cases was 61 years and 60.5% were women. Over 12 years of mean follow-up, the incidence rate (95% CI) of diabetes was 11.2 (10.90–11.50) per 1000 person years. Adjusted RRs (95% CI) for diabetes were 1.27 (1.15–1.41), 1.21 (1.08–1.35), 1.16 (1.04–1.28), and 0.99 (0.86–1.14) for younger women (age 20–64 years), older women (age ≥ 65 years), younger men, and older men, respectively. Conclusion. Younger adults and older women with OA have increased risks of developing diabetes compared to their age-sex matched non-OA counterparts. Further studies are needed to confirm these results and to elucidate the potential mechanisms.http://dx.doi.org/10.1155/2014/620920 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. Mushfiqur Rahman Jolanda Cibere Aslam H. Anis Charlie H. Goldsmith Jacek A. Kopec |
spellingShingle |
M. Mushfiqur Rahman Jolanda Cibere Aslam H. Anis Charlie H. Goldsmith Jacek A. Kopec Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study International Journal of Rheumatology |
author_facet |
M. Mushfiqur Rahman Jolanda Cibere Aslam H. Anis Charlie H. Goldsmith Jacek A. Kopec |
author_sort |
M. Mushfiqur Rahman |
title |
Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study |
title_short |
Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study |
title_full |
Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study |
title_fullStr |
Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study |
title_full_unstemmed |
Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study |
title_sort |
risk of type 2 diabetes among osteoarthritis patients in a prospective longitudinal study |
publisher |
Hindawi Limited |
series |
International Journal of Rheumatology |
issn |
1687-9260 1687-9279 |
publishDate |
2014-01-01 |
description |
Objectives. Our aim was to determine the risk of diabetes among osteoarthritis (OA) cases in a prospective longitudinal study. Methods. Administrative health records of 577,601 randomly selected individuals from British Columbia, Canada, from 1991 to 2009, were analyzed. OA and diabetes cases were identified by checking physician’s visits and hospital records. From 1991 to 1996 we documented 19,143 existing OA cases and selected one non-OA individual matched by age, sex, and year of administrative records. Poisson regression and Cox proportional hazards models were fitted to estimate the effects after adjusting for available sociodemographic and medical factors. Results. At baseline, the mean age of OA cases was 61 years and 60.5% were women. Over 12 years of mean follow-up, the incidence rate (95% CI) of diabetes was 11.2 (10.90–11.50) per 1000 person years. Adjusted RRs (95% CI) for diabetes were 1.27 (1.15–1.41), 1.21 (1.08–1.35), 1.16 (1.04–1.28), and 0.99 (0.86–1.14) for younger women (age 20–64 years), older women (age ≥ 65 years), younger men, and older men, respectively. Conclusion. Younger adults and older women with OA have increased risks of developing diabetes compared to their age-sex matched non-OA counterparts. Further studies are needed to confirm these results and to elucidate the potential mechanisms. |
url |
http://dx.doi.org/10.1155/2014/620920 |
work_keys_str_mv |
AT mmushfiqurrahman riskoftype2diabetesamongosteoarthritispatientsinaprospectivelongitudinalstudy AT jolandacibere riskoftype2diabetesamongosteoarthritispatientsinaprospectivelongitudinalstudy AT aslamhanis riskoftype2diabetesamongosteoarthritispatientsinaprospectivelongitudinalstudy AT charliehgoldsmith riskoftype2diabetesamongosteoarthritispatientsinaprospectivelongitudinalstudy AT jacekakopec riskoftype2diabetesamongosteoarthritispatientsinaprospectivelongitudinalstudy |
_version_ |
1725489708971065344 |