Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis

Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis

<p>Abstract</p> <p>Background</p> <p>Lung fibrosis is a devastating pulmonary disorder characterized by alveolar epithelial injury, extracellular matrix deposition and scar tissue formation. Due to its potent collagenolytic activity, cathepsin K, a lysosomal cysteine pr...

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Bibliographic Details
Main Authors: Buhling Frank, Länger Florian, Hoymann Heinz-Gerd, Morko Jukka, Kiviranta Riku, Steinwede Kathrin, Srivastava Mrigank, Welte Tobias, Maus Ulrich A
Format: Article
Language:English
Published: BMC 2008-07-01
Series:Respiratory Research
Online Access:http://respiratory-research.com/content/9/1/54

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