A molecular mechanism for transthyretin amyloidogenesis
A number of disease-causing human transthyretin (TTR) mutations are known to lead to amyloid formation. Here the authors combine neutron crystallography, native mass spectrometry and modelling studies to characterize the T119M and S52P-TTR mutants, providing mechanistic insights into TTR amyloidosis...
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Bibliographic Details
Main Authors: |
Ai Woon Yee,
Matteo Aldeghi,
Matthew P. Blakeley,
Andreas Ostermann,
Philippe J. Mas,
Martine Moulin,
Daniele de Sanctis,
Matthew W. Bowler,
Christoph Mueller-Dieckmann,
Edward P. Mitchell,
Michael Haertlein,
Bert L. de Groot,
Elisabetta Boeri Erba,
V. Trevor Forsyth |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2019-02-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-019-08609-z
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