Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers

Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers

Summary: Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to vaccination. The mechanisms of this inhibition are still debated. Using murine early-life immunization models mimicking the condition prevailing in humans, we observed the induction of CD4-T, T folli...

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Bibliographic Details
Main Authors: Maria Vono, Christiane Sigrid Eberhardt, Floriane Auderset, Beatris Mastelic-Gavillet, Sylvain Lemeille, Dennis Christensen, Peter Andersen, Paul-Henri Lambert, Claire-Anne Siegrist
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719309519

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http://www.sciencedirect.com/science/article/pii/S2211124719309519

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