LncRNAs in the Type I Interferon Antiviral Response
The proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases an...
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doaj-d32dd76aca8c42f8b7964e256c5f6e762020-11-25T01:26:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-01216447644710.3390/ijms21176447LncRNAs in the Type I Interferon Antiviral ResponseBeatriz Suarez0Laura Prats-Mari1Juan P. Unfried2Puri Fortes3Program of Gene Therapy and Hepatology, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), 31008 Pamplona, SpainProgram of Gene Therapy and Hepatology, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), 31008 Pamplona, SpainProgram of Gene Therapy and Hepatology, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), 31008 Pamplona, SpainProgram of Gene Therapy and Hepatology, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), 31008 Pamplona, SpainThe proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases and cancer. Control over the magnitude and duration of the antiviral immune response is exerted by a finely tuned positive or negative regulation at the DNA, RNA, and protein level of members of the type I interferon (IFN) signaling pathways and on the expression and activity of antiviral and proinflammatory factors. As summarized in this review, committed research during the last decade has shown that several of these processes are exquisitely regulated by long non-coding RNAs (lncRNAs), transcripts with poor coding capacity, but highly versatile functions. After infection, viruses, and the antiviral response they trigger, deregulate the expression of a subset of specific lncRNAs that function to promote or repress viral replication by inactivating or potentiating the antiviral response, respectively. These IFN-related lncRNAs are also highly tissue- and cell-type-specific, rendering them as promising biomarkers or therapeutic candidates to modulate specific stages of the antiviral immune response with fewer adverse effects.https://www.mdpi.com/1422-0067/21/17/6447LncRNAstype I IFNantiviral response |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Beatriz Suarez Laura Prats-Mari Juan P. Unfried Puri Fortes |
spellingShingle |
Beatriz Suarez Laura Prats-Mari Juan P. Unfried Puri Fortes LncRNAs in the Type I Interferon Antiviral Response International Journal of Molecular Sciences LncRNAs type I IFN antiviral response |
author_facet |
Beatriz Suarez Laura Prats-Mari Juan P. Unfried Puri Fortes |
author_sort |
Beatriz Suarez |
title |
LncRNAs in the Type I Interferon Antiviral Response |
title_short |
LncRNAs in the Type I Interferon Antiviral Response |
title_full |
LncRNAs in the Type I Interferon Antiviral Response |
title_fullStr |
LncRNAs in the Type I Interferon Antiviral Response |
title_full_unstemmed |
LncRNAs in the Type I Interferon Antiviral Response |
title_sort |
lncrnas in the type i interferon antiviral response |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-09-01 |
description |
The proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases and cancer. Control over the magnitude and duration of the antiviral immune response is exerted by a finely tuned positive or negative regulation at the DNA, RNA, and protein level of members of the type I interferon (IFN) signaling pathways and on the expression and activity of antiviral and proinflammatory factors. As summarized in this review, committed research during the last decade has shown that several of these processes are exquisitely regulated by long non-coding RNAs (lncRNAs), transcripts with poor coding capacity, but highly versatile functions. After infection, viruses, and the antiviral response they trigger, deregulate the expression of a subset of specific lncRNAs that function to promote or repress viral replication by inactivating or potentiating the antiviral response, respectively. These IFN-related lncRNAs are also highly tissue- and cell-type-specific, rendering them as promising biomarkers or therapeutic candidates to modulate specific stages of the antiviral immune response with fewer adverse effects. |
topic |
LncRNAs type I IFN antiviral response |
url |
https://www.mdpi.com/1422-0067/21/17/6447 |
work_keys_str_mv |
AT beatrizsuarez lncrnasinthetypeiinterferonantiviralresponse AT laurapratsmari lncrnasinthetypeiinterferonantiviralresponse AT juanpunfried lncrnasinthetypeiinterferonantiviralresponse AT purifortes lncrnasinthetypeiinterferonantiviralresponse |
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1725107842496593920 |