LncRNAs in the Type I Interferon Antiviral Response

The proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases an...

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Main Authors: Beatriz Suarez, Laura Prats-Mari, Juan P. Unfried, Puri Fortes
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/17/6447
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spelling doaj-d32dd76aca8c42f8b7964e256c5f6e762020-11-25T01:26:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-01216447644710.3390/ijms21176447LncRNAs in the Type I Interferon Antiviral ResponseBeatriz Suarez0Laura Prats-Mari1Juan P. Unfried2Puri Fortes3Program of Gene Therapy and Hepatology, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), 31008 Pamplona, SpainProgram of Gene Therapy and Hepatology, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), 31008 Pamplona, SpainProgram of Gene Therapy and Hepatology, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), 31008 Pamplona, SpainProgram of Gene Therapy and Hepatology, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), 31008 Pamplona, SpainThe proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases and cancer. Control over the magnitude and duration of the antiviral immune response is exerted by a finely tuned positive or negative regulation at the DNA, RNA, and protein level of members of the type I interferon (IFN) signaling pathways and on the expression and activity of antiviral and proinflammatory factors. As summarized in this review, committed research during the last decade has shown that several of these processes are exquisitely regulated by long non-coding RNAs (lncRNAs), transcripts with poor coding capacity, but highly versatile functions. After infection, viruses, and the antiviral response they trigger, deregulate the expression of a subset of specific lncRNAs that function to promote or repress viral replication by inactivating or potentiating the antiviral response, respectively. These IFN-related lncRNAs are also highly tissue- and cell-type-specific, rendering them as promising biomarkers or therapeutic candidates to modulate specific stages of the antiviral immune response with fewer adverse effects.https://www.mdpi.com/1422-0067/21/17/6447LncRNAstype I IFNantiviral response
collection DOAJ
language English
format Article
sources DOAJ
author Beatriz Suarez
Laura Prats-Mari
Juan P. Unfried
Puri Fortes
spellingShingle Beatriz Suarez
Laura Prats-Mari
Juan P. Unfried
Puri Fortes
LncRNAs in the Type I Interferon Antiviral Response
International Journal of Molecular Sciences
LncRNAs
type I IFN
antiviral response
author_facet Beatriz Suarez
Laura Prats-Mari
Juan P. Unfried
Puri Fortes
author_sort Beatriz Suarez
title LncRNAs in the Type I Interferon Antiviral Response
title_short LncRNAs in the Type I Interferon Antiviral Response
title_full LncRNAs in the Type I Interferon Antiviral Response
title_fullStr LncRNAs in the Type I Interferon Antiviral Response
title_full_unstemmed LncRNAs in the Type I Interferon Antiviral Response
title_sort lncrnas in the type i interferon antiviral response
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2020-09-01
description The proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases and cancer. Control over the magnitude and duration of the antiviral immune response is exerted by a finely tuned positive or negative regulation at the DNA, RNA, and protein level of members of the type I interferon (IFN) signaling pathways and on the expression and activity of antiviral and proinflammatory factors. As summarized in this review, committed research during the last decade has shown that several of these processes are exquisitely regulated by long non-coding RNAs (lncRNAs), transcripts with poor coding capacity, but highly versatile functions. After infection, viruses, and the antiviral response they trigger, deregulate the expression of a subset of specific lncRNAs that function to promote or repress viral replication by inactivating or potentiating the antiviral response, respectively. These IFN-related lncRNAs are also highly tissue- and cell-type-specific, rendering them as promising biomarkers or therapeutic candidates to modulate specific stages of the antiviral immune response with fewer adverse effects.
topic LncRNAs
type I IFN
antiviral response
url https://www.mdpi.com/1422-0067/21/17/6447
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AT juanpunfried lncrnasinthetypeiinterferonantiviralresponse
AT purifortes lncrnasinthetypeiinterferonantiviralresponse
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