Sarcophine-Diol Inhibits Expression of COX-2, Inhibits Activity of cPLA2, Enhances Degradation of PLA2 and PLCγ1 and Inhibits Cell Membrane Permeability in Mouse Melanoma B16F10 Cells

Sarcophine-Diol Inhibits Expression of COX-2, Inhibits Activity of cPLA2, Enhances Degradation of PLA2 and PLCγ1 and Inhibits Cell Membrane Permeability in Mouse Melanoma B16F10 Cells

Sarcophine-diol (SD) is a semi-synthetic derivative of sarcophine with a significant chemopreventive effect against non-melanoma skin cancer both in vitro and in vivo. Recently, we have studied the effect of SD on melanoma development using the mouse melanoma B16F10 cell line. In this study, our fin...

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Bibliographic Details
Main Authors: Sherief Khalifa, Hesham Fahmy, Safwat A. Ahmed, Pratik Muley, Pawel T. Szymanski
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:Marine Drugs
Subjects:
melanoma
sarcophine
sarcophine-diol
skin cancer
Online Access:http://www.mdpi.com/1660-3397/10/10/2166

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