Time-resolved circular dichroism: Application to the study of conformal changes in biomolecules

Time-resolved circular dichroism: Application to the study of conformal changes in biomolecules

Circular dichroism (CD) is known to be a very sensitive probe of the conformation of molecules and biomolecules. It is therefore tempting to implement CD in a pump-probe experiment in order to measure ultrarapid conformational changes which occur in photochemical processes. We present two technic...

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Main Author: Hache F.
Format: Article
Language:English
Published: EDP Sciences 2010-06-01
Series:EPJ Web of Conferences
Online Access:http://dx.doi.org/10.1051/epjconf/20100503003
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spelling doaj-d3314e4f99884d249304ab1be4c140712021-08-02T06:38:05ZengEDP SciencesEPJ Web of Conferences2100-014X2010-06-0150300310.1051/epjconf/20100503003Time-resolved circular dichroism: Application to the study of conformal changes in biomoleculesHache F.Circular dichroism (CD) is known to be a very sensitive probe of the conformation of molecules and biomolecules. It is therefore tempting to implement CD in a pump-probe experiment in order to measure ultrarapid conformational changes which occur in photochemical processes. We present two technical developments of such time-resolved CD experiments. The first one relies on the modulation of the probe polarization from left to right circular whereas the second one measures the pump-induced ellipticity of the probe with a Babinet-Soleil compensator. Some applications are described and extension of these techniques towards the study of elementary protein folding processes is discussed. http://dx.doi.org/10.1051/epjconf/20100503003
collection DOAJ
language English
format Article
sources DOAJ
author Hache F.
spellingShingle Hache F.
Time-resolved circular dichroism: Application to the study of conformal changes in biomolecules
EPJ Web of Conferences
author_facet Hache F.
author_sort Hache F.
title Time-resolved circular dichroism: Application to the study of conformal changes in biomolecules
title_short Time-resolved circular dichroism: Application to the study of conformal changes in biomolecules
title_full Time-resolved circular dichroism: Application to the study of conformal changes in biomolecules
title_fullStr Time-resolved circular dichroism: Application to the study of conformal changes in biomolecules
title_full_unstemmed Time-resolved circular dichroism: Application to the study of conformal changes in biomolecules
title_sort time-resolved circular dichroism: application to the study of conformal changes in biomolecules
publisher EDP Sciences
series EPJ Web of Conferences
issn 2100-014X
publishDate 2010-06-01
description Circular dichroism (CD) is known to be a very sensitive probe of the conformation of molecules and biomolecules. It is therefore tempting to implement CD in a pump-probe experiment in order to measure ultrarapid conformational changes which occur in photochemical processes. We present two technical developments of such time-resolved CD experiments. The first one relies on the modulation of the probe polarization from left to right circular whereas the second one measures the pump-induced ellipticity of the probe with a Babinet-Soleil compensator. Some applications are described and extension of these techniques towards the study of elementary protein folding processes is discussed.
url http://dx.doi.org/10.1051/epjconf/20100503003
work_keys_str_mv AT hachef timeresolvedcirculardichroismapplicationtothestudyofconformalchangesinbiomolecules
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