Antimicrobial Sensitivity Testing of <i>Mycoplasma bovis</i> Isolates Derived from Western Canadian Feedlot Cattle
<i>Mycoplasma bovis</i> is particularly adept at evading the immune system, resulting in chronic infections of the lungs and joints of feedlot cattle. The chronicity of the lesions results in prolonged antimicrobial therapy, possibly exacerbating antimicrobial resistance. This cross-sect...
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doaj-d331cfcbf8624993b6a7a21c0c8151262020-11-25T01:42:36ZengMDPI AGMicroorganisms2076-26072020-01-018112410.3390/microorganisms8010124microorganisms8010124Antimicrobial Sensitivity Testing of <i>Mycoplasma bovis</i> Isolates Derived from Western Canadian Feedlot CattleMurray Jelinski0Andrea Kinnear1Karen Gesy2Sara Andrés-Lasheras3Rahat Zaheer4Scott Weese5Tim A. McAllister6Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, CanadaWestern College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, CanadaWestern College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, CanadaLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB T1J 4B1, CanadaLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB T1J 4B1, CanadaOntario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, CanadaLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB T1J 4B1, Canada<i>Mycoplasma bovis</i> is particularly adept at evading the immune system, resulting in chronic infections of the lungs and joints of feedlot cattle. The chronicity of the lesions results in prolonged antimicrobial therapy, possibly exacerbating antimicrobial resistance. This cross-sectional study generated in vitro antimicrobial susceptibility testing (AST) data on 211 <i>M. bovis</i> isolates recovered from 159 healthy, diseased, and dead cattle, spanning the period of 2006−2018. Nine antimicrobials commonly administered to western Canadian feedlot cattle were assessed. The data were analyzed with non-parametric statistical tests with a level of significance of <i>p</i> < 0.05 (two-tailed). Minimum inhibitory concentration (MIC) values tended to increase between the isolates from healthy versus dead cattle and over time (2006−2018). Isolates from dead versus healthy cattle were more likely to be resistant to tulathromycin, gamithromycin, tylosin and enrofloxacin. There was no difference in the distributions of the MICs generated from the isolates recovered from the lungs and joints (<i>p</i> ≥ 0.124) and the lungs and deep nasal passages (<i>p</i> ≥ 0.157) of the same animals.https://www.mdpi.com/2076-2607/8/1/124beeffeedlot<i>mycoplasma bovis</i>antimicrobialresistancesusceptibilitycanada |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Murray Jelinski Andrea Kinnear Karen Gesy Sara Andrés-Lasheras Rahat Zaheer Scott Weese Tim A. McAllister |
spellingShingle |
Murray Jelinski Andrea Kinnear Karen Gesy Sara Andrés-Lasheras Rahat Zaheer Scott Weese Tim A. McAllister Antimicrobial Sensitivity Testing of <i>Mycoplasma bovis</i> Isolates Derived from Western Canadian Feedlot Cattle Microorganisms beef feedlot <i>mycoplasma bovis</i> antimicrobial resistance susceptibility canada |
author_facet |
Murray Jelinski Andrea Kinnear Karen Gesy Sara Andrés-Lasheras Rahat Zaheer Scott Weese Tim A. McAllister |
author_sort |
Murray Jelinski |
title |
Antimicrobial Sensitivity Testing of <i>Mycoplasma bovis</i> Isolates Derived from Western Canadian Feedlot Cattle |
title_short |
Antimicrobial Sensitivity Testing of <i>Mycoplasma bovis</i> Isolates Derived from Western Canadian Feedlot Cattle |
title_full |
Antimicrobial Sensitivity Testing of <i>Mycoplasma bovis</i> Isolates Derived from Western Canadian Feedlot Cattle |
title_fullStr |
Antimicrobial Sensitivity Testing of <i>Mycoplasma bovis</i> Isolates Derived from Western Canadian Feedlot Cattle |
title_full_unstemmed |
Antimicrobial Sensitivity Testing of <i>Mycoplasma bovis</i> Isolates Derived from Western Canadian Feedlot Cattle |
title_sort |
antimicrobial sensitivity testing of <i>mycoplasma bovis</i> isolates derived from western canadian feedlot cattle |
publisher |
MDPI AG |
series |
Microorganisms |
issn |
2076-2607 |
publishDate |
2020-01-01 |
description |
<i>Mycoplasma bovis</i> is particularly adept at evading the immune system, resulting in chronic infections of the lungs and joints of feedlot cattle. The chronicity of the lesions results in prolonged antimicrobial therapy, possibly exacerbating antimicrobial resistance. This cross-sectional study generated in vitro antimicrobial susceptibility testing (AST) data on 211 <i>M. bovis</i> isolates recovered from 159 healthy, diseased, and dead cattle, spanning the period of 2006−2018. Nine antimicrobials commonly administered to western Canadian feedlot cattle were assessed. The data were analyzed with non-parametric statistical tests with a level of significance of <i>p</i> < 0.05 (two-tailed). Minimum inhibitory concentration (MIC) values tended to increase between the isolates from healthy versus dead cattle and over time (2006−2018). Isolates from dead versus healthy cattle were more likely to be resistant to tulathromycin, gamithromycin, tylosin and enrofloxacin. There was no difference in the distributions of the MICs generated from the isolates recovered from the lungs and joints (<i>p</i> ≥ 0.124) and the lungs and deep nasal passages (<i>p</i> ≥ 0.157) of the same animals. |
topic |
beef feedlot <i>mycoplasma bovis</i> antimicrobial resistance susceptibility canada |
url |
https://www.mdpi.com/2076-2607/8/1/124 |
work_keys_str_mv |
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