Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis

Endo180, a collagen binding receptor, is highly expressed in a subset of cancer-associated fibroblasts. The authors show, using knockout mice and 3D in vitro assays, that Endo180 depletion impairs tumour fibroblast contractility and viability resulting in reduced tumour growth and metastasis.

Bibliographic Details
Main Authors:	Ute Jungwirth, Antoinette van Weverwijk, Rachel J. Evans, Liam Jenkins, David Vicente, John Alexander, Qiong Gao, Syed Haider, Marjan Iravani, Clare M. Isacke
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23583-1

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spelling	doaj-d33b1b683b5f48278db9816c890eda302021-06-13T11:15:09ZengNature Publishing GroupNature Communications2041-17232021-06-0112111710.1038/s41467-021-23583-1Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasisUte Jungwirth0Antoinette van Weverwijk1Rachel J. Evans2Liam Jenkins3David Vicente4John Alexander5Qiong Gao6Syed Haider7Marjan Iravani8Clare M. Isacke9The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchEndo180, a collagen binding receptor, is highly expressed in a subset of cancer-associated fibroblasts. The authors show, using knockout mice and 3D in vitro assays, that Endo180 depletion impairs tumour fibroblast contractility and viability resulting in reduced tumour growth and metastasis.https://doi.org/10.1038/s41467-021-23583-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ute Jungwirth Antoinette van Weverwijk Rachel J. Evans Liam Jenkins David Vicente John Alexander Qiong Gao Syed Haider Marjan Iravani Clare M. Isacke
spellingShingle	Ute Jungwirth Antoinette van Weverwijk Rachel J. Evans Liam Jenkins David Vicente John Alexander Qiong Gao Syed Haider Marjan Iravani Clare M. Isacke Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis Nature Communications
author_facet	Ute Jungwirth Antoinette van Weverwijk Rachel J. Evans Liam Jenkins David Vicente John Alexander Qiong Gao Syed Haider Marjan Iravani Clare M. Isacke
author_sort	Ute Jungwirth
title	Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
title_short	Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
title_full	Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
title_fullStr	Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
title_full_unstemmed	Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
title_sort	impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-06-01
description	Endo180, a collagen binding receptor, is highly expressed in a subset of cancer-associated fibroblasts. The authors show, using knockout mice and 3D in vitro assays, that Endo180 depletion impairs tumour fibroblast contractility and viability resulting in reduced tumour growth and metastasis.
url	https://doi.org/10.1038/s41467-021-23583-1
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Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis

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