Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
Endo180, a collagen binding receptor, is highly expressed in a subset of cancer-associated fibroblasts. The authors show, using knockout mice and 3D in vitro assays, that Endo180 depletion impairs tumour fibroblast contractility and viability resulting in reduced tumour growth and metastasis.
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2021-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-23583-1 |
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doaj-d33b1b683b5f48278db9816c890eda302021-06-13T11:15:09ZengNature Publishing GroupNature Communications2041-17232021-06-0112111710.1038/s41467-021-23583-1Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasisUte Jungwirth0Antoinette van Weverwijk1Rachel J. Evans2Liam Jenkins3David Vicente4John Alexander5Qiong Gao6Syed Haider7Marjan Iravani8Clare M. Isacke9The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer ResearchEndo180, a collagen binding receptor, is highly expressed in a subset of cancer-associated fibroblasts. The authors show, using knockout mice and 3D in vitro assays, that Endo180 depletion impairs tumour fibroblast contractility and viability resulting in reduced tumour growth and metastasis.https://doi.org/10.1038/s41467-021-23583-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ute Jungwirth Antoinette van Weverwijk Rachel J. Evans Liam Jenkins David Vicente John Alexander Qiong Gao Syed Haider Marjan Iravani Clare M. Isacke |
spellingShingle |
Ute Jungwirth Antoinette van Weverwijk Rachel J. Evans Liam Jenkins David Vicente John Alexander Qiong Gao Syed Haider Marjan Iravani Clare M. Isacke Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis Nature Communications |
author_facet |
Ute Jungwirth Antoinette van Weverwijk Rachel J. Evans Liam Jenkins David Vicente John Alexander Qiong Gao Syed Haider Marjan Iravani Clare M. Isacke |
author_sort |
Ute Jungwirth |
title |
Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis |
title_short |
Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis |
title_full |
Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis |
title_fullStr |
Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis |
title_full_unstemmed |
Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis |
title_sort |
impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-06-01 |
description |
Endo180, a collagen binding receptor, is highly expressed in a subset of cancer-associated fibroblasts. The authors show, using knockout mice and 3D in vitro assays, that Endo180 depletion impairs tumour fibroblast contractility and viability resulting in reduced tumour growth and metastasis. |
url |
https://doi.org/10.1038/s41467-021-23583-1 |
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