Fitness landscape of a dynamic RNA structure.
RNA structures are dynamic. As a consequence, mutational effects can be hard to rationalize with reference to a single static native structure. We reasoned that deep mutational scanning experiments, which couple molecular function to fitness, should capture mutational effects across multiple conform...
Main Authors: | Valerie W C Soo, Jacob B Swadling, Andre J Faure, Tobias Warnecke |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-02-01
|
Series: | PLoS Genetics |
Online Access: | https://doi.org/10.1371/journal.pgen.1009353 |
Similar Items
-
The DNA-binding protein HTa from Thermoplasma acidophilum is an archaeal histone analog
by: Antoine Hocher, et al.
Published: (2019-11-01) -
Slaying the last unicorn: discovery of histones in the microalga Nanochlorum eucaryotum
by: Valerie W. C. Soo, et al.
Published: (2021-02-01) -
Comprehensive experimental fitness landscape and evolutionary network for small RNA
by: Jimenez Zarco, Jose I., et al.
Published: (2014) -
Exact evolutionary dynamics on multi dimensional fitness landscape
by: Makar Ghazaryan, et al.
Published: (2015-12-01) -
Evolutionary algorithms with clustering for dynamic fitness landscapes
by: Victoria S. Aragón, et al.
Published: (2005-12-01)