Broad Protection of Pigs against Heterologous PRRSV Strains by a GP5-Mosaic DNA Vaccine Prime/GP5-Mosaic rVaccinia (VACV) Vaccine Boost

Broad Protection of Pigs against Heterologous PRRSV Strains by a GP5-Mosaic DNA Vaccine Prime/GP5-Mosaic rVaccinia (VACV) Vaccine Boost

Background: Porcine reproductive and respiratory syndrome (PRRS) viruses are a major cause of disease and economic loss in pigs worldwide. High genetic diversity among PRRSV strains is problematic for successful disease control by vaccination. Mosaic DNA and vaccinia (VACV) vaccines were developed i...

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Bibliographic Details
Main Authors:	Junru Cui, Caitlin M. O’Connell, Connor Hagen, Kim Sawicki, Joan A. Smyth, Paulo H. Verardi, Herbert J. Van Kruiningen, Antonio E. Garmendia
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Vaccines
Subjects:	prrsv mosaic t-cell dna vaccine vacv prrs cross protection heterologous virus challenge
Online Access:	https://www.mdpi.com/2076-393X/8/1/106

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