Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature

Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature

Aggressive NK-cell leukemia is a rare malignancy with neoplastic proliferation of natural killer cells. It often presents with constitutional symptoms, a rapid declining clinical course, and a poor prognosis with a median survival of a few months. The disease is usually resistant to cytotoxic agents...

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Main Authors: Anders Kindberg Boysen, Paw Jensen, Preben Johansen, Karen Dybkær, Mette Nyegaard
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2011/818469
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spelling doaj-d344b6313bbd4347ac200d48d731f9c22020-11-24T20:54:32ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792011-01-01201110.1155/2011/818469818469Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the LiteratureAnders Kindberg Boysen0Paw Jensen1Preben Johansen2Karen Dybkær3Mette Nyegaard4Department of Hematology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, P.O. Box 365, 9100 Aalborg, DenmarkDepartment of Hematology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, P.O. Box 365, 9100 Aalborg, DenmarkDepartment of Pathology, Aalborg Hospital, Aarhus University Hospital, 9100 Aalborg, DenmarkDepartment of Hematology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, P.O. Box 365, 9100 Aalborg, DenmarkDepartment of Hematology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, P.O. Box 365, 9100 Aalborg, DenmarkAggressive NK-cell leukemia is a rare malignancy with neoplastic proliferation of natural killer cells. It often presents with constitutional symptoms, a rapid declining clinical course, and a poor prognosis with a median survival of a few months. The disease is usually resistant to cytotoxic agents, and no treatment has emerged as the standard of care for these patients. We report a case of an 18-year-old male who obtains complete remission following two lines of combination chemotherapy. We describe in details our regimens for induction chemotherapy and perform a review of existing literature concerning treatment of aggressive NK-cell leukemia.http://dx.doi.org/10.1155/2011/818469
collection DOAJ
language English
format Article
sources DOAJ
author Anders Kindberg Boysen
Paw Jensen
Preben Johansen
Karen Dybkær
Mette Nyegaard
spellingShingle Anders Kindberg Boysen
Paw Jensen
Preben Johansen
Karen Dybkær
Mette Nyegaard
Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature
Case Reports in Hematology
author_facet Anders Kindberg Boysen
Paw Jensen
Preben Johansen
Karen Dybkær
Mette Nyegaard
author_sort Anders Kindberg Boysen
title Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature
title_short Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature
title_full Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature
title_fullStr Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature
title_full_unstemmed Treatment of Aggressive NK-Cell Leukemia: A Case Report and Review of the Literature
title_sort treatment of aggressive nk-cell leukemia: a case report and review of the literature
publisher Hindawi Limited
series Case Reports in Hematology
issn 2090-6560
2090-6579
publishDate 2011-01-01
description Aggressive NK-cell leukemia is a rare malignancy with neoplastic proliferation of natural killer cells. It often presents with constitutional symptoms, a rapid declining clinical course, and a poor prognosis with a median survival of a few months. The disease is usually resistant to cytotoxic agents, and no treatment has emerged as the standard of care for these patients. We report a case of an 18-year-old male who obtains complete remission following two lines of combination chemotherapy. We describe in details our regimens for induction chemotherapy and perform a review of existing literature concerning treatment of aggressive NK-cell leukemia.
url http://dx.doi.org/10.1155/2011/818469
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AT pawjensen treatmentofaggressivenkcellleukemiaacasereportandreviewoftheliterature
AT prebenjohansen treatmentofaggressivenkcellleukemiaacasereportandreviewoftheliterature
AT karendybkær treatmentofaggressivenkcellleukemiaacasereportandreviewoftheliterature
AT mettenyegaard treatmentofaggressivenkcellleukemiaacasereportandreviewoftheliterature
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