Bio-Prospecting of a Few Brown Seaweeds for Their Cytotoxic and Antioxidant Activities
Methanolic extracts (MEs) of seven brown seaweeds occurring in the Indian coastal waters were screened for their cytotoxic and antioxidant properties following various assays. The methanolic extracts of seaweeds in the order of Dictyopteris australis > Spatoglossum variabile > Stoechospermum m...
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2011-01-01
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Online Access: | http://dx.doi.org/10.1093/ecam/neq024 |
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doaj-d34cef38822d4bfaaaf6375aa01b20702020-11-24T23:47:37ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882011-01-01201110.1093/ecam/neq024673083Bio-Prospecting of a Few Brown Seaweeds for Their Cytotoxic and Antioxidant ActivitiesRashmi C. Vinayak0A. S. Sabu1Anil Chatterji2Biological Oceanography Division, National Institute of Oceanography, Dona Paula, Goa 403004, IndiaBiological Oceanography Division, National Institute of Oceanography, Dona Paula, Goa 403004, IndiaBiological Oceanography Division, National Institute of Oceanography, Dona Paula, Goa 403004, IndiaMethanolic extracts (MEs) of seven brown seaweeds occurring in the Indian coastal waters were screened for their cytotoxic and antioxidant properties following various assays. The methanolic extracts of seaweeds in the order of Dictyopteris australis > Spatoglossum variabile > Stoechospermum marginatum > Spatoglossum aspermum showed significant cytotoxic activity. A very high DPPH radical scavenging activity was exhibited by the methanolic extracts prepared from St. marginatum, Padina tetrastromatica, Dictyopteris delicatula and S. aspermum. The total phenolic content of the MEs varied from 13.19 ± 0.32 to 25.29 ± 0.445 gallic acid equivalents (mg g−1 of methanolic extract). The reducing power assay indicated a dose dependency, at concentrations of 0.1, 0.5 and 1.0 and 2.0 mg mL−1 of MEs and decreased in the following order: Butylated hydroxy toluene > P. tetrastromatica > D. delicatula > S. aspermum > S. variabile > S. marginatum > D. australis > S. marginatum. Furthermore, D. australis, S. aspermum, S. variabile and S. marginatum demonstrated good metal ion chelating properties. All the above evidences suggest that, the antioxidant compounds found in brown seaweeds scavenge free radicals through effective intervention. This decisively promotes them as a potential source of natural antioxidants.http://dx.doi.org/10.1093/ecam/neq024 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rashmi C. Vinayak A. S. Sabu Anil Chatterji |
spellingShingle |
Rashmi C. Vinayak A. S. Sabu Anil Chatterji Bio-Prospecting of a Few Brown Seaweeds for Their Cytotoxic and Antioxidant Activities Evidence-Based Complementary and Alternative Medicine |
author_facet |
Rashmi C. Vinayak A. S. Sabu Anil Chatterji |
author_sort |
Rashmi C. Vinayak |
title |
Bio-Prospecting of a Few Brown Seaweeds for Their Cytotoxic and Antioxidant Activities |
title_short |
Bio-Prospecting of a Few Brown Seaweeds for Their Cytotoxic and Antioxidant Activities |
title_full |
Bio-Prospecting of a Few Brown Seaweeds for Their Cytotoxic and Antioxidant Activities |
title_fullStr |
Bio-Prospecting of a Few Brown Seaweeds for Their Cytotoxic and Antioxidant Activities |
title_full_unstemmed |
Bio-Prospecting of a Few Brown Seaweeds for Their Cytotoxic and Antioxidant Activities |
title_sort |
bio-prospecting of a few brown seaweeds for their cytotoxic and antioxidant activities |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2011-01-01 |
description |
Methanolic extracts (MEs) of seven brown seaweeds occurring in the Indian coastal waters were screened for their cytotoxic and antioxidant properties following various assays. The methanolic extracts of seaweeds in the order of Dictyopteris australis > Spatoglossum variabile > Stoechospermum marginatum > Spatoglossum aspermum showed significant cytotoxic activity. A very high DPPH radical scavenging activity was exhibited by the methanolic extracts prepared from St. marginatum, Padina tetrastromatica, Dictyopteris delicatula and S. aspermum. The total phenolic content of the MEs varied from 13.19 ± 0.32 to 25.29 ± 0.445 gallic acid equivalents (mg g−1 of methanolic extract). The reducing power assay indicated a dose dependency, at concentrations of 0.1, 0.5 and 1.0 and 2.0 mg mL−1 of MEs and decreased in the following order: Butylated hydroxy toluene > P. tetrastromatica > D. delicatula > S. aspermum > S. variabile > S. marginatum > D. australis > S. marginatum. Furthermore, D. australis, S. aspermum, S. variabile and S. marginatum demonstrated good metal ion chelating properties. All the above evidences suggest that, the antioxidant compounds found in brown seaweeds scavenge free radicals through effective intervention. This decisively promotes them as a potential source of natural antioxidants. |
url |
http://dx.doi.org/10.1093/ecam/neq024 |
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