RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity

RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity

In response to injuries to the CNS, astrocytes enter a reactive state known as astrogliosis, which is believed to be deleterious in some contexts. Activated astrocytes overexpress intermediate filaments including glial fibrillary acidic protein (GFAP) and vimentin (Vim), resulting in entangled cells...

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Bibliographic Details
Main Authors: Jayden A. Smith, Alice Braga, Jeroen Verheyen, Silvia Basilico, Sara Bandiera, Clara Alfaro-Cervello, Luca Peruzzotti-Jametti, Dan Shu, Farzin Haque, Peixuan Guo, Stefano Pluchino
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
RNA nanotherapeutics
astrocytes
Lipocalin2
astrogliosis
siRNA
pRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117302925

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http://www.sciencedirect.com/science/article/pii/S2162253117302925

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