Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome
Neoadjuvant chemotherapy is a therapeutic option for the treatment of breast cancer. Here, the authors characterize changes in the gene expression profiles and immune microenvironment in serial breast cancer biopsies taken before, during and after neoadjuvant chemotherapy.
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Nature Publishing Group
2020-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19933-0 |
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doaj-d34ef5fb3216481893b451cd685dff302021-05-11T08:27:57ZengNature Publishing GroupNature Communications2041-17232020-12-0111111410.1038/s41467-020-19933-0Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcomeYeon Hee Park0Samir Lal1Jeong Eon Lee2Yoon-La Choi3Ji Wen4Sripad Ram5Ying Ding6Soo-Hyeon Lee7Eric Powell8Se Kyung Lee9Jong Han Yu10Keith A. Ching11Jae-Yong Nam12Seok Won Kim13Seok Jin Nam14Ji-Yeon Kim15Soo Youn Cho16Seri Park17Jinho Kim18Soohyn Hwang19Yu Jin Kim20Vinicius Bonato21Diane Fernandez22Shibing Deng23Shuoguo Wang24Hyuntae Shin25Eun-Suk Kang26Woong-Yang Park27Paul A. Rejto28Jadwiga Bienkowska29Zhengyan Kan30Samsung Medical CenterOncology Research & Development, PfizerSamsung Medical CenterSamsung Medical CenterOncology Research & Development, PfizerDrug Safety R&D, PfizerOncology Research & Development, PfizerPfizer OncologyOncology Research & Development, PfizerSamsung Medical CenterSamsung Medical CenterOncology Research & Development, PfizerSamsung Medical CenterSamsung Medical CenterSamsung Medical CenterSamsung Medical CenterSamsung Medical CenterSamsung Medical CenterSamsung Genome Institute, Samsung Medical CenterSamsung Medical CenterSamsung Medical CenterBiostatistics, PfizerOncology Research & Development, PfizerBiostatistics, PfizerOncology Research & Development, PfizerSamsung Genome Institute, Samsung Medical CenterSamsung Medical CenterSamsung Genome Institute, Samsung Medical CenterOncology Research & Development, PfizerOncology Research & Development, PfizerOncology Research & Development, PfizerNeoadjuvant chemotherapy is a therapeutic option for the treatment of breast cancer. Here, the authors characterize changes in the gene expression profiles and immune microenvironment in serial breast cancer biopsies taken before, during and after neoadjuvant chemotherapy.https://doi.org/10.1038/s41467-020-19933-0 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yeon Hee Park Samir Lal Jeong Eon Lee Yoon-La Choi Ji Wen Sripad Ram Ying Ding Soo-Hyeon Lee Eric Powell Se Kyung Lee Jong Han Yu Keith A. Ching Jae-Yong Nam Seok Won Kim Seok Jin Nam Ji-Yeon Kim Soo Youn Cho Seri Park Jinho Kim Soohyn Hwang Yu Jin Kim Vinicius Bonato Diane Fernandez Shibing Deng Shuoguo Wang Hyuntae Shin Eun-Suk Kang Woong-Yang Park Paul A. Rejto Jadwiga Bienkowska Zhengyan Kan |
| spellingShingle |
Yeon Hee Park Samir Lal Jeong Eon Lee Yoon-La Choi Ji Wen Sripad Ram Ying Ding Soo-Hyeon Lee Eric Powell Se Kyung Lee Jong Han Yu Keith A. Ching Jae-Yong Nam Seok Won Kim Seok Jin Nam Ji-Yeon Kim Soo Youn Cho Seri Park Jinho Kim Soohyn Hwang Yu Jin Kim Vinicius Bonato Diane Fernandez Shibing Deng Shuoguo Wang Hyuntae Shin Eun-Suk Kang Woong-Yang Park Paul A. Rejto Jadwiga Bienkowska Zhengyan Kan Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome Nature Communications |
| author_facet |
Yeon Hee Park Samir Lal Jeong Eon Lee Yoon-La Choi Ji Wen Sripad Ram Ying Ding Soo-Hyeon Lee Eric Powell Se Kyung Lee Jong Han Yu Keith A. Ching Jae-Yong Nam Seok Won Kim Seok Jin Nam Ji-Yeon Kim Soo Youn Cho Seri Park Jinho Kim Soohyn Hwang Yu Jin Kim Vinicius Bonato Diane Fernandez Shibing Deng Shuoguo Wang Hyuntae Shin Eun-Suk Kang Woong-Yang Park Paul A. Rejto Jadwiga Bienkowska Zhengyan Kan |
| author_sort |
Yeon Hee Park |
| title |
Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome |
| title_short |
Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome |
| title_full |
Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome |
| title_fullStr |
Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome |
| title_full_unstemmed |
Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome |
| title_sort |
chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-12-01 |
| description |
Neoadjuvant chemotherapy is a therapeutic option for the treatment of breast cancer. Here, the authors characterize changes in the gene expression profiles and immune microenvironment in serial breast cancer biopsies taken before, during and after neoadjuvant chemotherapy. |
| url |
https://doi.org/10.1038/s41467-020-19933-0 |
| work_keys_str_mv |
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