Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures
Purpose. To evaluate the aggressiveness of peripheral zone prostate cancer by correlating the Gleason score (GS) with the ratio of the diffusion tensor imaging (DTI) measures. Materials and Methods. Forty-two peripheral zone prostate tumors were imaged using DTI. Regions of interest focusing on the...
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2017-01-01
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Series: | Contrast Media & Molecular Imaging |
Online Access: | http://dx.doi.org/10.1155/2017/5678350 |
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doaj-d351e5b2120d4b849fda1134d76f6efa2020-11-24T23:34:59ZengHindawi-WileyContrast Media & Molecular Imaging1555-43091555-43172017-01-01201710.1155/2017/56783505678350Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging MeasuresAslihan Onay0Gokhan Ertas1Metin Vural2Omer Acar3Yesim Saglican4Bilgen Coskun5Sergin Akpek6Department of Radiology, Koç University School of Medicine, Istanbul, TurkeyDepartment of Biomedical Engineering, Yeditepe University, Istanbul, TurkeyDepartment of Radiology, VKF American Hospital, Istanbul, TurkeyDepartment of Urology, Koç University School of Medicine, Istanbul, TurkeyDepartment of Pathology, Acibadem University School of Medicine, Istanbul, TurkeyDepartment of Radiology, VKF American Hospital, Istanbul, TurkeyDepartment of Radiology, Koç University School of Medicine, Istanbul, TurkeyPurpose. To evaluate the aggressiveness of peripheral zone prostate cancer by correlating the Gleason score (GS) with the ratio of the diffusion tensor imaging (DTI) measures. Materials and Methods. Forty-two peripheral zone prostate tumors were imaged using DTI. Regions of interest focusing on the center of tumor foci and noncancerous tissue were used to extract statistical measures of mean diffusivity (MD) and fractional anisotroy (FA). Measure ratio was calculated by dividing tumor measure by noncancerous tissue measure. Results. Strong correlations are observable between GS and MD measures while weak correlations are present between GS and FA measures. Minimum tumor MD (MDmin) and the ratio of minimum MD (rMDmin) show the same highest correlation with GS (both ρ=-0.73). Between GS ≤ 7 (3 + 4) and GS ≥ 7 (4 + 3), differences are significant for all MD measures but for some FA measures. MD measures perform better than FA measures in discriminating GS ≥ 7 (4 + 3). Conclusion. Ratios of MD measures can be used in evaluation of peripheral zone prostate cancer aggressiveness; however tumor MD measures alone perform similarly.http://dx.doi.org/10.1155/2017/5678350 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aslihan Onay Gokhan Ertas Metin Vural Omer Acar Yesim Saglican Bilgen Coskun Sergin Akpek |
spellingShingle |
Aslihan Onay Gokhan Ertas Metin Vural Omer Acar Yesim Saglican Bilgen Coskun Sergin Akpek Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures Contrast Media & Molecular Imaging |
author_facet |
Aslihan Onay Gokhan Ertas Metin Vural Omer Acar Yesim Saglican Bilgen Coskun Sergin Akpek |
author_sort |
Aslihan Onay |
title |
Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures |
title_short |
Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures |
title_full |
Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures |
title_fullStr |
Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures |
title_full_unstemmed |
Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures |
title_sort |
evaluation of peripheral zone prostate cancer aggressiveness using the ratio of diffusion tensor imaging measures |
publisher |
Hindawi-Wiley |
series |
Contrast Media & Molecular Imaging |
issn |
1555-4309 1555-4317 |
publishDate |
2017-01-01 |
description |
Purpose. To evaluate the aggressiveness of peripheral zone prostate cancer by correlating the Gleason score (GS) with the ratio of the diffusion tensor imaging (DTI) measures. Materials and Methods. Forty-two peripheral zone prostate tumors were imaged using DTI. Regions of interest focusing on the center of tumor foci and noncancerous tissue were used to extract statistical measures of mean diffusivity (MD) and fractional anisotroy (FA). Measure ratio was calculated by dividing tumor measure by noncancerous tissue measure. Results. Strong correlations are observable between GS and MD measures while weak correlations are present between GS and FA measures. Minimum tumor MD (MDmin) and the ratio of minimum MD (rMDmin) show the same highest correlation with GS (both ρ=-0.73). Between GS ≤ 7 (3 + 4) and GS ≥ 7 (4 + 3), differences are significant for all MD measures but for some FA measures. MD measures perform better than FA measures in discriminating GS ≥ 7 (4 + 3). Conclusion. Ratios of MD measures can be used in evaluation of peripheral zone prostate cancer aggressiveness; however tumor MD measures alone perform similarly. |
url |
http://dx.doi.org/10.1155/2017/5678350 |
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