EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer

EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer

EPHA3, a member of the EPH family, is overexpressed in various cancers. We demonstrated previously that EPHA3 is associated with radiation resistance in head and neck cancer via the PTEN/Akt/EMT pathway; the inhibition of EPHA3 significantly enhances the efficacy of radiotherapy in vitro and in vivo...

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Bibliographic Details
Main Authors: Song Hee Kim, Byung Chul Kang, Daseul Seong, Won Hyeok Lee, Jae Hee An, Hyoung Uk Je, Hee Jeong Cha, Hyo Won Chang, Sang Yoon Kim, Seong Who Kim, Myung Woul Han
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomolecules
Subjects:
head and neck cancer
radioresistance
PTEN
EPHA3
C-myc
DNMT1
Online Access:https://www.mdpi.com/2218-273X/11/4/599

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