Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients
Introduction. Acute myocardial infarction is commonly known as heart attack. It is a multifactorial disease influenced by environmental and genetic factors.The objective of the present study was to investigate the association of the angiotensin II type 1 receptor gene A/C polymorphism in South India...
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Hindawi - SAGE Publishing
2009-09-01
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320309342758 |
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doaj-d35efbf307a24534aaae9d57e1b3a1282021-05-02T09:35:35ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1470-32032009-09-011010.1177/1470320309342758Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients Bhoomi Reddy Pullareddy Baddela Muni Venkata Srikanth Babu Kolla Venkata KarunakarJeedigunta Yasovanthi Potham Sampath KumarAnnam SharathAkka JyothyIntroduction. Acute myocardial infarction is commonly known as heart attack. It is a multifactorial disease influenced by environmental and genetic factors.The objective of the present study was to investigate the association of the angiotensin II type 1 receptor gene A/C polymorphism in South Indian myocardial infarction patients. Subjects and methods. The present study included a total number of 221 subjects (107 myocardial infarction patients and 114 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the angiotensin II type 1 receptor gene A/C polymorphism was determined by polymerase chain reaction. Results. Comparison of the lipid profiles between patients and controls showed that patients had statistically highly significant values (p=0.0001).The CC genotype of the angiotensin II type 1 receptor was not associated with myocardial infarction patients when compared to controls. CC vs. AA was χ 2 = 2.08, odds ratio 2.30, 95% confidence interval 0.72 — 7.23, and p value was 0.14. Conclusion. The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population.https://doi.org/10.1177/1470320309342758 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bhoomi Reddy Pullareddy Baddela Muni Venkata Srikanth Babu Kolla Venkata Karunakar Jeedigunta Yasovanthi Potham Sampath Kumar Annam Sharath Akka Jyothy |
spellingShingle |
Bhoomi Reddy Pullareddy Baddela Muni Venkata Srikanth Babu Kolla Venkata Karunakar Jeedigunta Yasovanthi Potham Sampath Kumar Annam Sharath Akka Jyothy Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Bhoomi Reddy Pullareddy Baddela Muni Venkata Srikanth Babu Kolla Venkata Karunakar Jeedigunta Yasovanthi Potham Sampath Kumar Annam Sharath Akka Jyothy |
author_sort |
Bhoomi Reddy Pullareddy |
title |
Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients |
title_short |
Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients |
title_full |
Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients |
title_fullStr |
Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients |
title_full_unstemmed |
Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients |
title_sort |
angiotensin ii type 1 receptor gene polymorphism in myocardial infarction patients |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1470-3203 |
publishDate |
2009-09-01 |
description |
Introduction. Acute myocardial infarction is commonly known as heart attack. It is a multifactorial disease influenced by environmental and genetic factors.The objective of the present study was to investigate the association of the angiotensin II type 1 receptor gene A/C polymorphism in South Indian myocardial infarction patients. Subjects and methods. The present study included a total number of 221 subjects (107 myocardial infarction patients and 114 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the angiotensin II type 1 receptor gene A/C polymorphism was determined by polymerase chain reaction. Results. Comparison of the lipid profiles between patients and controls showed that patients had statistically highly significant values (p=0.0001).The CC genotype of the angiotensin II type 1 receptor was not associated with myocardial infarction patients when compared to controls. CC vs. AA was χ 2 = 2.08, odds ratio 2.30, 95% confidence interval 0.72 — 7.23, and p value was 0.14. Conclusion. The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population. |
url |
https://doi.org/10.1177/1470320309342758 |
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