Case Report: Multi-Omics Analysis and CAR-T Treatment of a Chronic Myeloid Leukemia Blast Crisis Case 5 Years After the Discontinuation of TKI

Case Report: Multi-Omics Analysis and CAR-T Treatment of a Chronic Myeloid Leukemia Blast Crisis Case 5 Years After the Discontinuation of TKI

Most relapsed chronic myeloid leukemia (CML) patients after tyrosine kinase inhibitor (TKI) discontinuation are in a chronic phase and could achieve remission through restarting the TKI treatment. Here we reported a case of sudden lymphoid blast crisis after 67 months of TKI discontinuation and depi...

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Bibliographic Details
Main Authors: Ya-Ru Miao, Wen Liu, Zhaodong Zhong, Yong You, Yutong Tang, Weiming Li, Xiaojian Zhu, An-Yuan Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
discontinuation
blast crisis
CAR-T
TGF-β
single-cell sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.739871/full

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